New developmental mechanism of female reproductive organs
| Project/Area Number |
25860143
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General anatomy (including histology/embryology)
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
HARAGUCHI Ryuma 愛媛大学, 医学(系)研究科(研究院), 講師 (00423690)
|
|---|
| Research Collaborator |
KITAZAWA Sohei 愛媛大学, 大学院医学系研究科, 教授 (90186239)
KITAZAWA Riko 愛媛大学, 医学部附属病院, 准教授 (00273780)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 雌性生殖器 / ヘッジホッグ / 組織系譜 / 遺伝子改変マウス / ミュラー管 / ウォルフ管 / Shhシグナル / Genetic Lineage Tracing法 / 雄性生殖管 / 子宮 |
|---|
| Outline of Final Research Achievements |
In the female reproductive tract (FRT) formation, mullerian duct is a necessary for FRT derevative organs, which are the uterus and part of the vagina. On the other hand, there is also the opinion that male reproductive duct, a Wolffian duct, is required for female reproductive organs. In this research, we revealed that Shh signaling derived from Wolffian duct acts as a signaling molecule organizing FRT formation.In addition, by fate mapping studies using genetic lineage tracing method, we revealed that Shh sigunal responding cells directly contribut to uterus development.
|
Report
(3 results)
Research Products
(22 results)
-
-
-
[Journal Article] Disruption of the temporally regulated cloaca endodermal β-catenin signaling causes anorectal malformations.2014
Author(s)
Miyagawa S, Harada M, Matsumaru D, Tanaka K, Inoue C, Nakahara C, Haraguchi R, Matsushita S, Suzuki K, Nakagata N, Ng RC, Akita K, Lui VC, Yamada G.
-
Journal Title
Cell Death & Differentiation
Volume: 21
Pages: 990-7
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
