| Project/Area Number |
25860148
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 下垂体前葉 / 濾胞星状細胞 / S100βタンパク陽性細胞 / プロテオグリカン / 樹状細胞 / 細胞外マトリクス / バイグリカン |
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| Outline of Final Research Achievements |
S100β protein-expressing cells (folliculo-stellate cells) have a star-like appearance and are interconnected by cytoplasmic processes in the anterior pituitary gland. We reported that folliculo-stellate cells produce proteoglycans, which are components of the extracellular matrix (ECM) and are composed of a specific core protein substituted with covalently linked glycosaminoglycan chains. They also appear to possess multifunctional properties. Considering their pleiotropic features, folliculo-stellate cells are assumed to be of a heterogenous. They were classified into subtypes such as stem cells, progenitor cells, epithelial cells, astrocytes and dendritic cells. In the present study, we found a method for isolating dendritic cell-like folliculo-stellate cells by use of adherent activity to ECM and revealed their function. These findings bring a novel insight to the understanding of the mechanism of cellular arrangement in the anterior pituitary gland.
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