The analysis of the mechanism for morphological changes and functions in rat anterior pituitary cells by use of proteoglycans.
| Project/Area Number |
25860148
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 下垂体前葉 / 濾胞星状細胞 / S100βタンパク陽性細胞 / プロテオグリカン / 樹状細胞 / 細胞外マトリクス / バイグリカン |
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| Outline of Final Research Achievements |
S100β protein-expressing cells (folliculo-stellate cells) have a star-like appearance and are interconnected by cytoplasmic processes in the anterior pituitary gland. We reported that folliculo-stellate cells produce proteoglycans, which are components of the extracellular matrix (ECM) and are composed of a specific core protein substituted with covalently linked glycosaminoglycan chains. They also appear to possess multifunctional properties. Considering their pleiotropic features, folliculo-stellate cells are assumed to be of a heterogenous. They were classified into subtypes such as stem cells, progenitor cells, epithelial cells, astrocytes and dendritic cells. In the present study, we found a method for isolating dendritic cell-like folliculo-stellate cells by use of adherent activity to ECM and revealed their function. These findings bring a novel insight to the understanding of the mechanism of cellular arrangement in the anterior pituitary gland.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Isolation of dendritic-cell-like S100β-positive cells in rat anterior pituitary gland.2014
Author(s)
Kotaro Horiguchi, Ken Fujiwara, Saishu Yoshida, Masashi Higuchi, Takehiro Tsukada, Naoko Kanno, Takashi Yashiro, Kozue Tateno, Shunji Osako, Takako Kato, Yukio Kato
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Journal Title
Cell and Tissue Research
Volume: (印刷中)
Issue: 1
Pages: 301-308
DOI
Related Report
Peer Reviewed
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[Journal Article] Folliculostellate Cells Are Required for Laminin Release from Gonadotrophs in Rat Anterior Pituitary2014
Author(s)
Tsukada T, Fujiwara K, Horiguchi K, Azuma M, Ramadhani D, Tofrizal A, Batchuluun K, Maliza R, Syaidah R, Kikuchi M, Yashiro T
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Journal Title
ACTA HISTOCHEMICA ET CYTOCHEMICA
Volume: 47
Issue: 5
Pages: 239-245
DOI
NAID
ISSN
0044-5991, 1347-5800
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Expression of the heparin-binding growth factor midkine and its receptor, Ptprz1, in adult rat pituitary2014
Author(s)
Fujiwara K, Horiguchi K, Maliza R, Tofrizal A, Batchuluun K, Ramadhani D, Syaidah R, Tsukada T, Azuma M, Kikuchi M, Yashiro T
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Journal Title
Cell Tissue Res
Volume: 359
Issue: 3
Pages: 909-914
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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