| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Thymus-derived lymphocytes (T lymphocytes) or megakaryocytes predominantly express delayed rectifier K+-channels (Kv1.3) in their plasma membranes. The channels are also expressed in various types of cancer cells and are responsible for the proliferation or differentiation of cells. To reveal the involvement of the Kv1.3-channels in the development of embryonic kidneys, we examined the effects of a selective Kv1.3-channel inhibitor, margatoxin, on the growth of the isolated kidney rudiments. Since margatoxin worked to preserve the metanephric mesenchyme in the developing kidneys, Kv1.3-channels expressed in embryonic kidneys were thought to be involved in the differentiation of the metanephric mesenchyme.
|
