Ubiquitin-independent endosomal sorting of cytokine receptors

Research Project

Project/Area Number	25860161
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General physiology
Research Institution	Shinshu University
Principal Investigator	AMANO Yuji 信州大学, 学術研究院医学系, 助教 (50624681)
Research Collaborator	TAKESHITA Toshikazu 信州大学, 学術研究院医学系, 教授 (60212023) KOJIMA Katsuhiko 信州大学, 学術研究院医学系, 講師 (80345743) YOSHINO Kazuhisa 信州大学, 学術研究院医学系, 助教 (40551859)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	小胞輸送 / インターロイキン２受容体 / インターロイキン４受容体 / ユビキチン非依存性小胞輸送 / ユビキチン
Outline of Final Research Achievements	We had reported that ubiquitin-independent endosomal sorting mechanism of interleukin-2 receptor β (IL-2Rβ) and interleukin-4 receptor α (IL-4Rα）. Hrs, which is also involved in an ubiquitin-dependent endosomal sorting, binds the hydrophobic amino acids clusters of the receptors and sorts the receptors into endosomes. Here, we elucidated that the hydrophobic amino acids clusters act as endosomal sorting signal and suggest Hrs controls endosomal sorting by novel manner.