The dynamics of spatiotemporal dopamine release
| Project/Area Number |
25860169
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
SHINODA Yo 東京理科大学, 理工学部, 助教 (80403096)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | ドーパミン / CAPS2 |
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| Outline of Final Research Achievements |
I established the primary culture method of DAergic neuron from mouse mesencephalon. The subcellular distributions of CAPS2 in the DAergic neuron from VTA and SNc are clarified by using anti-CAPS2 and anti-calbindin antibodies. Primary cultured DAergic neurons from WT and CAPS2 KO mice shows that the release activity of DA is significantly reduced in the DAergic neuron from CAPS2 KO mice.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum.2014
Author(s)
Sadakata T, Kakegawa W, Shinoda Y, Hosono M, Katoh-Semba R, Sekine Y, Sato Y, Saruta C, Ishizaki Y, Yuzaki M, Kojima M, Furuichi T.
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Journal Title
PLoS One.
Volume: 9(6)
Issue: 6
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain.2013
Author(s)
Sadakata T, Kakegawa W, Shinoda Y, Hosono M, Katoh-Semba R, Sekine Y, Sato Y, Tanaka M, Iwasato T, Itohara S, Furuyama K, Kawaguchi Y, Ishizaki Y, Yuzaki M, Furuichi T.
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Journal Title
J Neurosci.
Volume: 33
Issue: 44
Pages: 17326-17334
DOI
Related Report
Peer Reviewed
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[Presentation] Tutorial contents on the INCF japan node platforms2014
Author(s)
Y. YAMAGUCHI, S. SATOH, T. IIJIMA, R. KANZAKI, T. FURUICHI, Y. SHINODA, S. KAKEI, S. MASAKI, H. WAGATSUMA, T. MIYAKAWA, K. TAKAO, H. IKENO, K. TANAKA, Y. OKAMURA-OHO, Y.OKUMURA, S. KAMAKURA1, Y. ISONO, Y. MORII, S. SUENAGA, S. USUI.
Organizer
Society for Neuroscience 44st Annual Meeting
Place of Presentation
Washington DC, US
Year and Date
2014-11-15
Related Report
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[Presentation] Cerebellar Development Transcriptome Database (CDT-DB) - Profiling of Spatio-Temporal Gene Expression During Postnatal Development of Mouse Brain.2014
Author(s)
Yo Shinoda, Akira Sato, Michinori Koebis, Tetsushi Sadakata, Noriyuki Morita, Michisuke Yuzaki, Takafumi Inoue, Hirozumi Nishibe, Yoko Yamaguchi, Teiichi Furuichi.
Organizer
INCF Japan Node International Workshop, Advances in Neuroinformatics 2014
Place of Presentation
埼玉 和光市：理研BSI
Year and Date
2014-09-26
Related Report
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