Physiological roles of TRPM2 in microglial functions
| Project/Area Number |
25860172
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Kyoto Prefectural University of Medicine (2014)
Okazaki Research Facilities, National Institutes of Natural Sciences (2013) |
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Principal Investigator |
KASHIO Makiko 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20631394)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | TRPM2 / レドックスシグナル / 温度 / インスリン |
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| Outline of Final Research Achievements |
Pancreatic b-cells secrete hypoglycemic insulin upon blood glucose elevation to keep its concentration in the range of physiological levels. Insulin secretion from pancreatic b-cell is well known to be mediated by KATP channel-dependent canonical pathway in which KATP channel closure by intracellular ATP elevation causes membrane depolarization and activation of voltage-dependent Ca channel. However, beside the canonical pathway, KATP channel-independet pathways are recently elucidated to be involved in insulin secretion. As one of them, we have clarified the involvement of TRPM2 function in insulin secretion focusing on redox signal-mediated TRPM2-sensitization leading its activation at body temperature.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] The thermosensitive TRPV3 channel contributes to rapid wound healing in oral epithelia.2015
Author(s)
Aijima R, Wang B, Takao T, Mihara H, Kashio M, Ohsaki Y, Zhang JQ, Mizuno A, Suzuki M, Yamashita Y, Masuko S, Goto M, Tominaga M, Kido MA
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Journal Title
FASEB J.
Volume: 29
Pages: 182-192
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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