| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Delayed sleep phase syndrome (DSPS) is one of the sleep disorder which shows delay of circadian phase to have difficulty in social life. After sleep deprivation of 24 hours, patient of this disorder cannot enter recovery sleep which healthy individuals have immediately after relief of sleep deprivation. It is reported that accumulation of adenosine in basal forebrain is involved in regulation of recovery sleep. Accordingly, I examined the possibility of involvement of adenosinergic signaling in defect of sleep regulation in DSPS using model mice. As a result, I obtained result which suggests alteration of expression of adenosine receptor between DSPS model mice and wild-type mice in basal forebrain.
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