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Structures that deliver the circadian rhythm from the suprachiasamtic nucleus to neighboring brain regions

Research Project

Project/Area Number 25860181
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionKinki University

Principal Investigator

MASUMOTO Kohei  近畿大学, 医学部, 助教 (60580529)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords体内時計 / 視交叉上核 / 室傍核 / 組織培養 / 概日リズム / 移殖 / グリア細胞
Outline of Final Research Achievements

The suprachiasmatic nucleus (SCN) is the center of circadian clock. In order to delineate what biological structure transmits circadian rhythm to paraventricular nucleus (PVN) and subparaventricular zone (SPZ) from the SCN, we observed the coherence between the circadian rhythms in the SCN and PVN/SPZ by monitoring bioluminescence emitted from tissue slice from Per2::luc knock-in mice. In slices containing SCN and PVN/SPZ, the two regions showed antiphasic circadian rhythm, in contrast, slices containing PVN/SPZ but not SCN showed a circadian rhythm which was damped after a few days. However, when the slice showing damped oscillation was co-cultured with the SCN slice, PVN/SPZ restored a stable circadian rhythm antiphasic to that in the SCN. The findings suggest that the structure maintaining the coherence between the circadian oscillations in the SCN and PVN/SPZ was reconstructed.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Regional circadian period difference in the suprachiasmatic nucleus of the mammalian circadian center.2013

    • Author(s)
      Koinuma S, Asakawa T, Nagano M, Furukawa K, Sujino M, Masumoto KH, Nakajima Y, Hashimoto S, Yagita K, Shigeyoshi Y.
    • Journal Title

      Eur J Neurosci.

      Volume: 38 Issue: 6 Pages: 2832-41

    • DOI

      10.1111/ejn.12308

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Establishment of TSH β real-time monitoring system in mammalian photoperiodism.2013

    • Author(s)
      Kaori Tsujino, Ryohei Narumi, Koh-hei Masumoto, Etsuo A. Susaki, Yuta Shinohara, Takaya Abe, Masayuki Iigo, Atsushi Wada, Mamoru Nagano, Yasufumi Shigeyoshi, Hiroki R. Ueda
    • Journal Title

      Genes to Cells

      Volume: 18 Issue: 7 Pages: 575-588

    • DOI

      10.1111/gtc.12063

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Circadian expression and specific localization of a sialyltransferase gene in the suprachiasmatic nucleus.2013

    • Author(s)
      Hamada Y, Saigoh K, Masumoto KH, Nagano M, Kusunoki S, Shigeyoshi Y.
    • Journal Title

      Neurosci Lett.

      Volume: 22;535 Pages: 12-7

    • DOI

      10.1016/j.neulet.2012.12.032

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Structures that deliver the circadian rhythm from the suprachiasamtic nucleus to neighboring brain regions2015

    • Author(s)
      Koh-hei Masumoto, Mamoru Nagano, Satoshi Koinuma, Mitsugu Sujino, Yasufumi Shigeyoshi
    • Organizer
      第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会 合同大会
    • Place of Presentation
      神戸国際会議場・展示場(神戸市)
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reproduction of the structure for the coherence between suprachiasmatic nucleus and other neighboring brain regions2014

    • Author(s)
      升本宏平、長野護、鯉沼聡、筋野貢、重吉康史
    • Organizer
      第21回日本時間生物学会学術大会
    • Place of Presentation
      九州大学医学部百年行動(福岡市)
    • Year and Date
      2014-11-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 視交叉上核と室傍核領域間の同調機構

    • Author(s)
      升本 宏平、長野 護、鯉沼 聡、筋野 貢、重吉 康史
    • Organizer
      第20回日本時間生物学会学術大会
    • Place of Presentation
      近畿大学,東大阪キャンパス(東大阪市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 光誘導相は主観的夜の限局された時刻に存在する

    • Author(s)
      升本宏平、長野護、重吉康史
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Research-status Report
  • [Book] Mechanism and Modeling of Circadian Phase Wave in the Mammalian Circadian Center2014

    • Author(s)
      Yasufumi Shigeyoshi, Takeshi Asakawa, Koh-hei Masumoto, Satoshi Koinuma and Mamoru Nagano
    • Total Pages
      17
    • Publisher
      北海道大学出版会
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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