| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Pulmonary hypertension (PH) causes cardiac hypertrophy in right ventricles (RV), and eventually leads to RV failure due to persistently elevated ventricular afterload. We hypothesized that the mechanical stress of RV associated with increased afterload impairs vasodilative function of the right coronary artery (RCA) in PH. Using microangiography, we compared the vascular function of RCA in the PH and control rats. Endothelium-dependent and -independent vasodilative responses were significantly attenuated in the middle and small arteries in the severe PH rats and the presence of abnormal constriction mechanism was revealed in the right coronary circulation of severe PH rat. The observed impaired vasodilative function of RCA in PH model suggests that impaired RCA function might have causal relationship with RV failure in the patients with severe PH.
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