Molecular pharmacological analysis of anti-inflammatory effects of PAI-1 inhibitor
Project/Area Number |
25860185
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General pharmacology
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Research Institution | Kyoto University (2014) Tohoku University (2013) |
Principal Investigator |
ATSUHIKO Ichimura 京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 (10609209)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 分子薬理学 / 創薬 / 炎症 / 薬理学 / 糖尿病 / 肥満 / 代謝 |
Outline of Final Research Achievements |
This research was conducted with the aim to elucidate the molecular pharmacological mechanism of anti-inflammatory effect of PAI-1 inhibitors. The suitable pathological model of inflammation to evaluate efficacy of PAI-1 inhibitors was searched. As a result, we have successfully found anti-inflammatory effect of PAI-1 inhibitors on high fat diet (HFD)-induced obesity model. PAI-1 inhibitors attenuated HFD-induced impaired systemic glucose and energy metabolism. Further analyses of molecular mechanisms of the efficacy of PAI-1 inhibitors demonstrated that PAI-1 inhibitors suppressed accumulation of fat in adipocyte accompanying with the inhibition of infiltration of inflammatory macrophages into adipose tissue and the liver. These results suggest the possibility of PAI-1 inhibitors as novel therapeutic agent of metabolic disorders.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.2015
Author(s)
Mashiko S, Kitatani K, Toyoshima M, Ichimura A, Dan T, Usui T, Ishibashi M, Shigeta S, Nagase S, Miyata T, Yaegashi N
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Journal Title
Cancer Biology & Therapy
Volume: 16
Issue: 2
Pages: 253-260
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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