Roles of prostanoid during premetastatic niche formation in regional lymph node
| Project/Area Number |
25860192
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | リンパ管新生 / プロスタグランジン / リンパ節転移 / がん / 慢性炎症 / ノックアウトマウス |
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| Outline of Final Research Achievements |
Lymph node metastasis (LNM) is a critical prognostic factor in cancer patients. Our study revealed that endogenous COX-2-derived PGE2 stimulated the EP3 receptor on DCs, leading to theupregulation of SDF-1 expression in the subcapsular regions in regional lymph nodes following LLC cell injection into the lungs. SDF-1 upregulation facilitated the accumulation of CXCR4+ LLC cells and the formation of the regional lymph node premetastatic niche. We also found that accumulation of Tregs and lymph node lymphangiogenesis, both of which may decide the fate of metastasized tumor cells, were COX-2/EP3-dependent. Taken together, our findings suggest that PGE2inhibitors, together with SDF-1 receptor antagonists and EP3 antagonists, may be promising agents for the suppression of premetastatic niche formation and LNM.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the up regulation of epidermal growth factor expression on VEGFR1+ CXCR4+ cells recruited from bone marrow.2014
Author(s)
Sato T., Amano H., Ito Y., Eshima K., Minamino T., Ae T., Katada C., Ohno T., Hosono K., Suzuki T., Shibuya M., Koizumi W., Majima M.
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Journal Title
J Gastroenterol
Volume: 49
Pages: 455-469
DOI
Related Report
Peer Reviewed
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[Journal Article] Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment.2013
Author(s)
Ohkubo H., Ito Y., Minamino T., Mishima T., Hirata M., Hosono K., Shibuya M., Yokomizo T., Shimizu T., Watanabe M., Majima M.
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Journal Title
FASEB J
Volume: 27
Pages: 3132-3143
DOI
Related Report
Peer Reviewed
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