| Project/Area Number |
25860193
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | アデノシン / 脳虚血 / ATP / 低体温療法 / 海馬 / 薬理学 / 神経科学 |
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| Outline of Final Research Achievements |
The therapeutic hypothermia for acute stroke might play an important role in neuroprotection, however, the key mechanism of this therapy is still undetermined. We hypothesize that hypothermia enhances ATP/adenosine-mediated neuroprotection against ischemia. To elucidate this hypothesis, we recorded filed EPSPs from stratum radiatum of area CA1 in the acute hippocampal slices of adult mice and oxygen-glucose deprivation (the model of ischemia in vitro) was exposed while changing temperatures. The results suggest that hypothermia has protective effect on ischemia-induced loss of synaptic activity through activation of adenosine receptors.
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