The involvement of ATP/adenosine in the therapeutic hypothermia for brain ischemia
| Project/Area Number |
25860193
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Jikei University School of Medicine |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | アデノシン / 脳虚血 / ATP / 低体温療法 / 海馬 / 薬理学 / 神経科学 |
|---|
| Outline of Final Research Achievements |
The therapeutic hypothermia for acute stroke might play an important role in neuroprotection, however, the key mechanism of this therapy is still undetermined. We hypothesize that hypothermia enhances ATP/adenosine-mediated neuroprotection against ischemia. To elucidate this hypothesis, we recorded filed EPSPs from stratum radiatum of area CA1 in the acute hippocampal slices of adult mice and oxygen-glucose deprivation (the model of ischemia in vitro) was exposed while changing temperatures. The results suggest that hypothermia has protective effect on ischemia-induced loss of synaptic activity through activation of adenosine receptors.
|
Report
(3 results)
Research Products
(2 results)
