Three dimensional imaging for the investigation of the mechanisms of generation and propagation of automaticity in the pulmonary vein myocardium
| Project/Area Number |
25860194
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
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| Research Collaborator |
TANAKA Hikaru
TAKAHARA Akira
KAWANISHI Toru
TANAKA Naoko
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 薬理学 / 肺静脈心筋 / イメージング / 自動能 / 心房細動 / 自発活動 |
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| Outline of Final Research Achievements |
We recorded the spontaneous automaticity from the myocardial layer of isolated pulmonary veins with high-speed 3-demensional confocal microscopy and glass microelectrode technique. Spontaneous automaticity was observed in isolated pulmonary vein preparations and firing frequency was enhanced by noradrenaline, while reduced by acetylcholine. Noradrenaline affected the resting membrane potential and induced local calcium oscillations followed by spontaneous automaticity. These results indicated that spontaneous automaticity of the pulmonary vein myocardium is influenced by autonomic neurotransmitters.
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Report
(5 results)
Research Products
(79 results)
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[Journal Article] Manifestation of automaticity in the pulmonary-vein myocardium of rats with abdominal aorto-venocaval shunt.2015
Author(s)
Shogo Hamaguchi, Yayoi Tsuneoka, Ayumi Tanaka, Masahiko Irie, Masato Tsuruta, Takahiro Nakayama, Iyuki Namekata, Mizuki Nada, Megumi Aimoto, Akira Takahara, Hikaru Tanaka.
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Journal Title
Journal of Pharmaceutical Sciences
Volume: 128
Pages: 212-215
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.2015
Author(s)
Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y
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Journal Title
The Journal of Clinical Investigation
Volume: 124
Pages: 2785-2801
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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