Effects of Lidocaine derivatives on cancer pain; the specific blockade of primary sensory neurons expressing transient receptor potential channels.
| Project/Area Number |
25860199
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Miyano Kanako 国立研究開発法人国立がん研究センター, 研究所, 研究員 (50597888)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | TRP / 疼痛 / がん / 抗がん剤 / 末梢神経障害 |
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| Outline of Final Research Achievements |
There are not many cancer patients receiving well-controlled pain management, and therefore the development of more effective analgesics are required now. In recent years, it revealed that transient receptor potential (TRP) channels expressing primary sensory neurons played an important role for cancer pain. Moreover, it was reported that QX-314, which was one of the derivatives of lidocaine, a local anesthetic, suppressed the activation of voltage-gated sodium channel (Nav) in neurons expressing both TRP and Nav. However, the detailed pharmacological and/or analgesic actions of lidocaine derivatives are not well known.
In this study, therefore, we focused on the derivatives of lidocaine for development of novel analgesics, which specifically block TRP-expressing nerves, and evaluated the pharmacologic actions of these lidocaine derivatives on cancer pain.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Metabolism of AM404 from acetaminophen at human therapeutic dosages in the rat brain.2016
Author(s)
Muramatsu. S., Shiraishi, S., Miyano, K., Sudo, Y., Toda, A., Mogi, M., Hara, M., Yokoyama, A., Kawasaki. Y., Taniguchi, M., Uezono, Y.
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Journal Title
Anesth Pain Med
Volume: 6
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca2+ influx through transient receptor potential V1 (TRPV1) channels.2016
Author(s)
Murakami, S., Sudo, Y., Miyano, K., Nishimura, H., Matoba, M., Shiraishi, S., Konno, H., Uezono, Y.
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Journal Title
J Pharmacol Sci
Volume: 130
Issue: 2
Pages: 72-77
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The atypical antipsychotic, olanzapine, potentiates ghrelin-induced receptor signaling: An in vitro study with cells expressing cloned human growth hormone secretagogue receptor.2015
Author(s)
Tagami K, Kashiwase Y, Yokoyama A, Nishimura H, Miyano K, Suzuki M, Shiraishi S, Matoba M, Ohe Y, Uezono Y
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Journal Title
Neuropeptides
Volume: -
Pages: 93-101
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tricyclic antidepressant amitriptyline-induced glial cell line-derived neurotrophic factor production involves pertussis toxin-sensitive Gαi/o activation in astroglial cells.2015
Author(s)
Hisaoka-Nakashima K, Miyano K, Matsumoto C, Kajitani N, Abe H, Okada-Tsuchioka M, Yokoyama A, Uezono Y, Morioka N, Nakata Y, Takebayashi M.
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Journal Title
J Biol Chem
Volume: 290
Issue: 22
Pages: 13678-13691
DOI
Related Report
Peer Reviewed
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[Journal Article] Tramadol and its metabolite m1 selectively suppress transient receptor potential ankyrin 1 activity, but not transient receptor potential vanilloid 1 activity2015
Author(s)
Miyano K, Minami K, Yokoyama T, Ohbuchi K, Yamaguchi T, Murakami S, Shiraishi S, Yamamoto M, Matoba M, Uezono Y.
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Journal Title
Anesth Analg
Volume: 120(4)
Issue: 4
Pages: 790-798
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats.2015
Author(s)
Hitomi S, Ono K, Miyano K, Ota Y, Uezono Y, Matoba M, Kuramitsu S, Yamaguchi K, Matsuo K, Seta Y, Harano N, Inenaga K.
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Journal Title
J Neurosci Methods
Volume: 239
Pages: 162-169
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] History of the G Protein–Coupled Receptor (GPCR) Assays From Traditional to a State-of-the-Art Biosensor Assay2014
Author(s)
Miyano K, Sudo Y, Yokoyama A, Hisaoka-Nakashima K, Morioka N, Takebayashi M, Shiraishi S, Nakata Y, Higami Y, Uezono Y.
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Journal Title
Journal of Pharmacological Sciences
Volume: 126
Issue: 4
Pages: 302-309
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line.2014
Author(s)
Terawaki K, Sawada Y, Kashiwase Y, Hashimoto H, Yoshimura M, Suzuki M, Miyano K, Sudo Y, Shiraishi S, Higami Y, Yanagihara K, Kase Y, Ueta Y, Uezono Y
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Journal Title
Am J Physiol Endocrinol Metab.
Volume: 306(4)
Issue: 4
Pages: 373-87
DOI
Related Report
Peer Reviewed
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[Presentation] A novel assay for detecting the activation of G protein-coupled receptors using cellular dielectric spectroscopy.2015
Author(s)
Miyano K, Sudo Y, Yokoyama A, Nishimura H, Kawaida M, Sato S, Nemoto E, Nakashima K, Takebayashi M, Morioka N, Shiraishi S, Higami Y, Fujii H, Nakata Y, Uezono Y.
Organizer
第88回日本薬理学会年会
Place of Presentation
名古屋国際会議場（愛知県・名古屋市）
Year and Date
2015-03-18
Related Report
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