Regulation of NF-kappaB signalling by MARCH9

Research Project

Project/Area Number	25860207
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General medical chemistry
Research Institution	Gunma University
Principal Investigator	GOTO EIJI 群馬大学, 生体調節研究所, 助教 (40435649)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	ユビキチン / NF-κB
Outline of Final Research Achievements	Nuclear factor-κB (NF-κB) is activated by various stimuli, including cellular stresses, UV irradiation and cytokines. NF-κB is essential for immune and inflammatory responses, and abnormal NF-κB signalling is implicated in multiple diseases. In the present study, we identified MARCH9 as a new candidate protein for regulation of NF-κB signalling. Further detailed study of MARCH9 will provide clues as to the underlying cause of multiple NF-κB-related diseases.