Research Project
Grant-in-Aid for Young Scientists (B)
I established a transgenic mouse line in which Pdx1 and Isl1 could be inducibly expressed in the acinar cells. My results showed that acinar-derived EGFP-positive insulin producing cells appear by induction of both Pdx1 and Isl1 in adult exocrine cells. Overexpression of the factors necessary for transdifferentiaion using lentivirul vectors in sorted EGFP-positive acinar cells induced acinar-to-beta cell transdifferentiation. Although further study is required, my result provides a promise for the in vitro transdifferentiation of exocrine cells to beta cells.
All 2014 2013
All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (1 results)
Surgery Frontier
Volume: 21 Pages: 62-66
PLoS One
Volume: 8 Issue: 8 Pages: e71645-e71645
10.1371/journal.pone.0071645
Elife
Volume: 2
10.7554/elife.00940