Analysis of mitochondrial homeostasis through PINK1 kinase
Project/Area Number |
25860216
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
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Research Institution | Okayama University |
Principal Investigator |
Murata Hitoshi 岡山大学, 医歯(薬)学総合研究科, 講師 (90579096)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | PINK1 / ミトコンドリア / ストレス / SARM1 / NRF2 / 活性酸素種 / 酸化ストレス / マイトファジー / TRAF6 |
Outline of Final Research Achievements |
We analyzed the mechanism of mitochondrial homeostasis through PINK1 which is one of the causing gene products of Parkinson's disease. In transcriptional regulation, we found that NRF2, an antioxidant transcription factor, regulates PINK1 expression under oxidative stress condition. In post-translational regulation, we found that SARM1 and TRAF6 bind to and stabilize PINK1 through lysine 63 chain ubiquitination. Accumulated PINK1 contributes to damaged mitochondrial degradation and cell survival.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes2014
Author(s)
Sakaguchi M, Murata H, Aoyama Y, Hibino T, Putranto EW, Ruma IM, Inoue Y, Sakaguchi Y, Yamamoto K, Kinoshita R, Futami J, Kataoka K, Iwatsuki K, Huh NH
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Journal Title
J Biol Chem
Volume: 289
Issue: 34
Pages: 23389-23402
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the Cargo Gene2014
Author(s)
Sakaguchi M, Watanabe M, Kinoshita R, Kaku H, Ueki H, Futami J, Murata H, Inoue Y, Li SA, Huang P, Putranto EW, Ruma IM, Nasu Y, Kumon H, Huh NH
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Journal Title
Molecular Biotechnology
Volume: 印刷中
Related Report
Peer Reviewed
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