Analysis of neuronal cell death triggered by mitochondrial aggregation
Project/Area Number |
25860224
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
|
Research Institution | Kyushu University (2014) Tokyo Medical University (2013) |
Principal Investigator |
KATO Hiroki 九州大学, 歯学研究科(研究院), 助教 (30452709)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | ミトコンドリア / 神経変性疾患 / 凝集 |
Outline of Final Research Achievements |
Abnormal mitochondrial distribution and aggregation at perinuclear region in neuronal cells became to be recognized as one of the cause of neurodegenerative disease. We previously reported that deletion mutants of prion protein localize to mitochondria and induce mitochondrial aggregation. In addition, we showed that 14-3-3 zeta is essential for mitochondrial aggregation. In this study, we found that 14-3-3 gamma, eta and Tom70 are also involved in mitochondrial aggregation evoked by prion protein.
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Report
(3 results)
Research Products
(11 results)