• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study on the brain-specific ncRNA related to mental disorder

Research Project

Project/Area Number 25860239
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionHiroshima University

Principal Investigator

FURUMAI Ryohei  広島大学, 医歯薬保健学研究院, 特任助教 (30450414)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsノンコーディングRNA / プラダーウィリー症候群 / 次世代シークエンサー / マイクロRNA
Outline of Final Research Achievements

Brain-specific non-coding RNA (ncRNA) responsible for the pathogenesis of Prader-Willie syndrome, a rare developmental/mental disorder, was knock-downed in the primary cultured neurons obtained from wild type mouse brain. Then we compared the global transcriptome between control and knock-downed neurons by next-generation sequencer. As a result, we found that the expressions of several genes and miRNAs were significantly changed in knock-downed neurons. Our finding suggested that transcriptional changes in these genes/miRNAs in knock-downed neurons could be related to the etiology of Prader-Willie syndrome.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi