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Identification and characterization of a novel unknown glycosyltransferase GTUF in breast cancer cells

Research Project

Project/Area Number 25860240
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionIwate Medical University (2014)
The University of Tokushima (2013)

Principal Investigator

MATSUO Taisuke  岩手医科大学, 薬学部, 助教 (70533222)

Research Collaborator KATAGIRI Toyomasa  徳島大学, 疾患プロテオゲノム研究センター, 教授 (60291895)
ONO Masaya  国立がんセンター研究所, 化学療法部, 室長 (00270900)
MIYOSHI Yasuo  兵庫医科大学, 医学部, 教授 (50283784)
BANDO Yoshimi  徳島大学病院, 准教授 (00238239)
SASA Mitsunori  とくしまブレストケアクリニック
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords乳癌 / 糖転移酵素
Outline of Final Research Achievements

In this study, we report the critical role of an unknown glycosyltransferase GTUF (GlycosylTransferase of Unknown Function) in breast cancer cells. Although GTUF was frequently up-regulated in breast cancer cells, including triple negative breast cancer (TNBC) cells, it was not significantly expressed in normal tissues. Knockdown of GTUF by siRNA significantly suppressed cell growth and induced apoptosis in both TNBC and non-TNBC cells. GTUF has two glycosylated sites and its glycosylation is important for secretion into culture medium from cells. These results suggested that GTUF might be a novel therapeutic target and molecular marker of breast cancer.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (7 results)

  • [Journal Article] Early growth response 4 is involved in cell proliferation of small cell lung cancer through transcriptional activation of its downstream genes.2014

    • Author(s)
      Matsuo T, Dat le T, Komatsu M, Yoshimaru T, Daizumoto K, Sone S, Nishioka Y, Katagiri T.
    • Journal Title

      PLoS One

      Volume: 20

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of B3GALNT2 overexpression in the cell growth of breast cancer.2014

    • Author(s)
      Matsuo T, Komatsu M, Yoshimaru T, Kiyotani K, Miyoshi Y, Sasa M, Katagiri T.
    • Journal Title

      International Journal of Oncology

      Volume: 44 Pages: 427-434

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells.2013

    • Author(s)
      Yoshimaru T, Komatsu M, Matsuo T, Chen YA, Murakami Y, Mizuguchi K, Mizohata E, Inoue T, Akiyama M, Yamaguchi R, Imoto S, Miyano S, Miyoshi Y, Sasa M, Nakamura Y, Katagiri T.
    • Journal Title

      Nature Communications

      Volume: 4 Pages: 2443-2443

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 悪性度の高いトリプルネガティブ乳癌における核内19S-proteasome関連遺伝子(nPAG1)の役割2014

    • Author(s)
      小松正人、吉丸哲郎、尾野雅哉、松尾泰佑、清谷一馬、三好康雄、笹三徳、片桐豊雅
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 乳癌細胞における癌抑制分子PHB2 のエストロゲン依存性核内移行機構の解明2014

    • Author(s)
      金南希、吉丸哲郎、小松正人、松尾泰佑、笹三徳、片桐豊雅
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] トリプルネガティブ乳癌におけるプロテアソーム構成因子のプロテアソーム活性非依存的な役割2014

    • Author(s)
      小松正人、吉丸哲郎、松尾泰佑、片桐豊雅
    • Organizer
      第18回日本がん分子標的治療学会学術集会
    • Place of Presentation
      仙台市情報・産業プラザ、ホテルメトロポリタン仙台、TKPガーデンシティ仙台(宮城県)
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] エストロゲン受容体制御分子BIG3を標的とした新規ER陽性乳がん治療法の創製2014

    • Author(s)
      吉丸哲郎、小松正人、松尾泰佑、片桐豊雅
    • Organizer
      第18回日本がん分子標的治療学会学術集会
    • Place of Presentation
      仙台市情報・産業プラザ、ホテルメトロポリタン仙台、TKPガーデンシティ仙台(宮城県)
    • Year and Date
      2014-06-25 – 2014-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] がん特異的糖転移酵素BCGT1 による小胞体ストレス制御を介した新規乳癌細胞増殖機構の解明2013

    • Author(s)
      松尾泰佑、尾野雅哉、吉丸哲郎、小松正人、三好康雄、笹三徳、片桐豊雅
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 19S プロテアソーム構成遺伝子PAG1 の核内過剰発現はトリプルネガティブ乳癌の増殖に関与する2013

    • Author(s)
      小松正人、吉丸哲郎、松尾泰佑、清谷一馬、三好康雄、笹三徳、片桐豊雅
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] エストロゲン受容体活性化制御分子ERAP1 と腫瘍抑制因子REAの相互作用を標的とした内分泌療法耐性乳癌の治療法の開発2013

    • Author(s)
      吉丸哲郎、小松正人、松尾泰佑、三好康雄、笹三徳、中村祐輔、片桐豊雅
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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