| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
SETDB1 is a histone methyltransferase that methylates lysine 9 on histone H3. We found that a post-translational modification of hSETDB1 is important to regulate its methyltransferase activity. Moreover, we identified the regions necessary for interaction between hSETDB1 and hMCAF1. Finally, we showed that nuclear hSETDB1 might be degraded by the proteasome and exported to the cytosol. Theses findings will be useful for regulating hSETDB1 function.
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