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Mechanism of the age-related increase of the chromosomal segregation errors during oogenesis in humans

Research Project

Project/Area Number 25860255
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human genetics
Research InstitutionFujita Health University

Principal Investigator

TSUTSUMI Makiko  藤田保健衛生大学, 総合医科学研究所, 助教 (30377907)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords減数分裂 / 卵母細胞 / 高齢出産 / 不妊症 / 習慣流産 / コヒーシンの減少 / 染色体の分離異常
Outline of Final Research Achievements

In humans, age-related increase of aneuploidy in oocytes is known as one of the causes of the birth of offspring with Down’s syndrome or miscarriage. It has been suggested that the decrease of the molecules, cohesins, involving chromosome segregation in meiosis contributes aneuploidy. To verify this hypothesis, in this study, I examined the amount of cohesins in human oocytes on the ovarian tissue sections. It was demonstrated that meiosis-specific cohesin subunits significantly decreased in women in their 40s compared to around 20 years old. These results suggest that the decrease of meiotic cohesins impairs the sister chromatid cohesion with age to induce segregation error, and aneuploid oocytes are formed.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) Remarks (2 results)

  • [Journal Article] Age-related decrease of meiotic cohesins in human oocyte2014

    • Author(s)
      Tsutsumi M, Fujiwara R, Nishizawa H, Ito M, Kogo H, Inagaki H, Ohye T, Kato T, Fujii T, Kurahashi H
    • Journal Title

      PLoS One

      Volume: 9, Issue: 5 Pages: 1-8

    • DOI

      10.1371/journal.pone.0096710

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Decrease of meiotic cohesins with maternal age in human oocytes2014

    • Author(s)
      Tsutsumi, R. Fujiwara, H. Nishizawa, H. Kogo, H. Inagaki, T. Ohye, T. Kato, T. Fujii, H. Kurahashi
    • Organizer
      2014年ヨーロッパ人類遺伝学会
    • Place of Presentation
      ミラノ・コングレッション(イタリア)
    • Year and Date
      2014-05-31 – 2014-06-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Decrease of meiotic cohesins with maternal age in human oocytes2014

    • Author(s)
      Makiko Tsutsumi, Reiko Fujiwara, Haruki Nishizawa, Hiroshi Kogo, Hidehito Inagaki, Tamae Ohye, Takema Kato, Hiroki Kurahashi
    • Organizer
      The EUROPEAN HUMAN GENETICS CONFERENCE 2014
    • Place of Presentation
      ミラノ(イタリア)
    • Related Report
      2013 Research-status Report
  • [Presentation] Age-related decrease of meiotic cohesins in human oocytes2013

    • Author(s)
      Makiko Tsutsumi, Reiko Fujiwara, Haruki Nishizawa, Hiroshi Kogo, Hidehito Inagaki, Tamae Ohye, Takema Kato, Hiroki Kurahashi
    • Organizer
      アメリカ人類遺伝学会第63回大会
    • Place of Presentation
      ボストン(アメリカ合衆国)
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト卵母細胞における加齢依存性染色体分離異常の発生機構2013

    • Author(s)
      堤真紀子, 藤原怜子, 池田怜美, 西澤春紀, 向後 寛, 稲垣秀人, 大江瑞恵, 加藤武馬, 倉橋浩樹
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      仙台市(宮城県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Mechanism of age-related increase of chromosome segregation error in human oocytes2013

    • Author(s)
      堤真紀子, 藤原怜子, 池田怜美, 西澤春紀, 向後 寛, 稲垣秀人, 大江瑞恵, 加藤武馬, 倉橋浩樹
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸市(兵庫県)
    • Related Report
      2013 Research-status Report
  • [Remarks] 分子遺伝学研究部門プレスリリース

    • URL

      http://info.fujita-hu.ac.jp/~genome/mg/_userdata/20.pdf

    • Related Report
      2014 Annual Research Report
  • [Remarks] 藤田保健衛生大学総合医科学研究所トピックス

    • URL

      http://www.fujita-hu.ac.jp/ICMS/topics/29_5369fedfb7073/index.html

    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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