Mechanism of the age-related increase of the chromosomal segregation errors during oogenesis in humans
| Project/Area Number |
25860255
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human genetics
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| Research Institution | Fujita Health University |
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Principal Investigator |
TSUTSUMI Makiko 藤田保健衛生大学, 総合医科学研究所, 助教 (30377907)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 減数分裂 / 卵母細胞 / 高齢出産 / 不妊症 / 習慣流産 / コヒーシンの減少 / 染色体の分離異常 |
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| Outline of Final Research Achievements |
In humans, age-related increase of aneuploidy in oocytes is known as one of the causes of the birth of offspring with Down’s syndrome or miscarriage. It has been suggested that the decrease of the molecules, cohesins, involving chromosome segregation in meiosis contributes aneuploidy. To verify this hypothesis, in this study, I examined the amount of cohesins in human oocytes on the ovarian tissue sections. It was demonstrated that meiosis-specific cohesin subunits significantly decreased in women in their 40s compared to around 20 years old. These results suggest that the decrease of meiotic cohesins impairs the sister chromatid cohesion with age to induce segregation error, and aneuploid oocytes are formed.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Age-related decrease of meiotic cohesins in human oocyte2014
Author(s)
Tsutsumi M, Fujiwara R, Nishizawa H, Ito M, Kogo H, Inagaki H, Ohye T, Kato T, Fujii T, Kurahashi H
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Journal Title
PLoS One
Volume: 9,
Issue: 5
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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