The roles of EBV-encoded microRNAs in the regulation of apoptosis and carcinogenesis
Project/Area Number |
25860262
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | Epstein-Barr ウイルス / アポトーシス / 胃癌 / microRNA / EBV / マイクロRNA |
Outline of Final Research Achievements |
To clarify the roles of EBV-encoded microRNAs in gastric carcinogenesis, surgically resected gastric carcinoma tissues and gastric carcinoma cell lines were analyzed. Comprehensive expression profiling of EBV-encoded microRNAs revealed several EBV microRNAs were highly expressed. Genes which are potentially targeted by these microRNAs were identified by in silico analysis. In vitro study showed ebv-miR-BART4-5p inhibits Bid, one of the apoptosis activators, which leads to resistance to apoptosis.
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Report
(3 results)
Research Products
(8 results)
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[Presentation] EBV関連胃癌2015
Author(s)
牛久 綾
Organizer
第104回日本病理学会総会
Place of Presentation
名古屋国際会議場(愛知県名古屋市)
Year and Date
2015-04-30 – 2015-05-02
Related Report
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