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Elucidation of EVI1 molecular network in pancreatic carcinogenesis

Research Project

Project/Area Number 25860263
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionThe University of Tokyo

Principal Investigator

TANAKA Mariko  東京大学, 医学(系)研究科(研究院), 助教 (50645710)

Research Collaborator 深山 正久  
石川 俊平  
砂河 孝行  
鈴木 洋  
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵癌 / 発癌 / 分化異常 / EVI1 / KRAS / microRNA / 膵臓癌 / 胃上皮化生
Outline of Final Research Achievements

Pancreatic cancer typically manifests a very poor prognosis. The precise mechanism of pancreatic carcinogensis is still unclear. Although an activating point mutation of KRAS is an early event in pancreatic carcinogenesis, it remains unclear whether KRAS mutation is solely responsible for initiation of pancreatic carcinogenesis. By tracking potential transcriptional regulators of gastric epithelial genes in pancreatic neoplasms, we found that overt expression of ecotropic viral integration site 1 (EVI1) oncoprotein is a hallmark of human pancreatic cancer and its precursors. In pancreatic cancer cells, EVI1 poses the oncogenic role by upregulating KRAS expression through suppression of a potent KRAS suppressor, miR-96. Results suggest that EVI1 oncoprotein and KRAS mutation converge on activation of the KRAS pathway in the early phase of pancreatic carcinogenesis and implicate EVI1 and/or miR-96 as candidate early markers and therapeutic targets in pancreatic cancer.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results)

  • [Journal Article] EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis.2014

    • Author(s)
      Tanaka M, Suzuki HI, Shibahara J, Kunita A, Isagawa T, Yoshimi A, Kurokawa M, Miyazono K, Aburatani H, Ishikawa S, Fukayama M.
    • Journal Title

      Oncogene

      Volume: 33(19) Issue: 19 Pages: 2454-63

    • DOI

      10.1038/onc.2013.204

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acoustic radiation force impulse imaging of the pancreas for estimation of pathologic fibrosis and risk of postoperative pancreatic fistula.2014

    • Author(s)
      Harada N, Ishizawa T, Inoue Y, Aoki T, Sakamoto Y, Hasegawa K, Sugawara Y, Tanaka M, Fukayama M, Kokudo N.
    • Journal Title

      J Am Coll Surg

      Volume: 219 Issue: 5 Pages: 887-94

    • DOI

      10.1016/j.jamcollsurg.2014.07.940

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A R0 resection case of initially unresectable metastatic pancreatic cancer downstaged by FOLFIRINOX therapy.2014

    • Author(s)
      Sasaki T, Isayama H, Aoki T, Tanaka M, Hamada T, Nakai Y, Sakamoto Y, Hasegawa K, Morikawa T, Fukayama M, Kokudo N, Koike K.
    • Journal Title

      Pancreas

      Volume: 43 Issue: 6 Pages: 972-4

    • DOI

      10.1097/mpa.0000000000000139

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Slow pull versus suction in endoscopic ultrasound-guided fine-needle aspiration of pancreatic solid masses.2014

    • Author(s)
      Nakai Y, Isayama H, Chang KJ, Yamamoto N, Hamada T, Uchino R, Mizuno S, Miyabayashi K, Yamamoto K, Kawakubo K, Kogure H, Sasaki T, Hirano K, Tanaka M, Tada M, Fukayama M, Koike K.
    • Journal Title

      Dig Dis Sci.

      Volume: 59 Issue: 7 Pages: 1578-85

    • DOI

      10.1007/s10620-013-3019-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed

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Published: 2014-07-25   Modified: 2019-07-29  

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