The clinicopathological and international joint research of enteropathy-associated T-cell lymphoma

• Project/Area Number: 25860278
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Tokai University
• Principal Investigator: TOMITA Sakura 東海大学, 医学部附属病院, 臨床助手 (20647507)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: EATL / 免疫組織化学 / in situ hybridization / aCGH / 9q34 gain / 腸管症型T細胞リンパ腫

Outline of Final Research Achievements

Enteropathy-associated T-cell lymphoma (EATL) is a rare primary T-cell lymphoma of the digestive tract. I aimed to clarify the characteristics of EATL in Japan using FFPE (formalin-fixed paraffin-embedded tissue).
EATL in Japan is characterized by medium to large sized cells with cytotoxic CD8(+)/CD56(+) immunophenotype and 9q34 gain irrespective of the cell origin of αβ-T-cells, γδ-T-cells and TCR silent cells.

Research Products

• [Int'l Joint Research] IDIBAPS, University of Barcelona(スペイン)
• [Journal Article] Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan. (2015)
  • Author(s): Tomita S, Kikuti YY, Carreras J, Kojima M, Ando K, Takasaki H, Sakai R, Takata K, Yoshino T, Bea S, Campo E, Nakamura N.
  • Journal Title: Modern Pathology Volume: 28 Issue: 10 Pages: 1286-96
  • DOI: 10.1038/modpathol.2015.85
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] GENOMIC AND IMMUNOHISTOCHEMICAL PROFILES OF ENTEROPATHY-ASSOCIATED T-CELL LYMPHOMA IN JAPAN. (2015)
  • Author(s): Sakura Tomita, Yara Y Kikuti, Joaquim Carreras Esteban, Minoru Kojima, Kiyoshi Ando, Hirotaka Takasaki, Rika Sakai, Katsuyoshi Takata, Tadashi Yoshino, Silvia Bea, Elias Campo and Naoya Nakamura
  • Organizer: Asia Pacific International Academy of Pathology Congress
  • Place of Presentation: オーストラリア, ブリスベン
  • Year and Date: 2015-06-05
  • Int'l Joint Research
• [Presentation] 腸管症型T細胞リンパ腫の免疫組織化学および遺伝子学的研究 (2014)
  • Author(s): 冨田さくら
  • Organizer: 日本リンパ網内系学会
  • Place of Presentation: 山形国際ホテル
  • Year and Date: 2014-06-20 – 2014-06-21
• [Presentation] 腸管症型T細胞リンパ腫の免疫組織化学および遺伝子学的研究 (2013)
  • Author(s): 冨田さくら
  • Organizer: 日本病理学会
  • Place of Presentation: ロイトン札幌