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Molecular mechanism of budding formation in colon cancer metastasis.

Research Project

Project/Area Number 25860289
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionThe University of Tokyo

Principal Investigator

Kunita Akiko  東京大学, 医学(系)研究科(研究院), 助教 (50608768)

Co-Investigator(Renkei-kenkyūsha) MORIKAWA Teppei  東京大学, 大学院医学系研究科, 准教授 (80451772)
Research Collaborator TAKESHITA Kimiko  東京大学, 医学部, 学術支援職員
SAKUMA Kei  東京大学, 医学部, 技術専門職員
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords大腸がん / 浸潤
Outline of Final Research Achievements

In order to investigate the mechanisms of budding formation in colon cancer lymph node metastasis,colon cancer specimens which shows budding were collected, and examined the metastasis-related molecule; podoplanin expression by immunohistochemistry. Podoplanin was expressed at the budding site and active fibroblast.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (23 results)

All 2016 2015 2014 2013

All Journal Article (11 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 11 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (12 results)

  • [Journal Article] Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by EBV.2016

    • Author(s)
      Saju P, Kamiya MN, Hayashi T, Senda Y, Nagase L, Noda S, Matsusaka K, Funata S, Kunita A, Urabe M, Seto Y, Fukayama M, Kaneda A, Hatakeyama M.
    • Journal Title

      Nat Microbiol

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults2016

    • Author(s)
      Takahiko Yasuda, Shinobu Tsuzuki, Masahito Kawazu, Fumihiko Hayakawa, Shinya Kojima, Toshihide Ueno, Naoto Imoto, Shinji Kohsaka, Akiko Kunita, Koichiro Doi, Toru Sakura, Toshiaki Yujiri, Eisei Kondo, Katsumichi Fujimaki, Yasunori Ueda, Yasutaka Aoyama, Shigeki Ohtake, Junko Takita, Eirin Sai, Masafumi Taniwaki, et al.
    • Journal Title

      Nature genetics

      Volume: in press Issue: 5 Pages: 409-417

    • DOI

      10.1038/ng.3535

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gut wall replacing type of gastrointestinal stromal tumor presenting as a perforation of the ileal diverticulum.2015

    • Author(s)
      Ikemura M, Kunita A, Miwa Y, Jimbo K, Mori K, Seto Y, Fukayama M.
    • Journal Title

      Pathol. Res. Prac

      Volume: 211 Issue: 11 Pages: 392-5

    • DOI

      10.1016/j.prp.2015.05.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The chimeric antibody chLpMab-7 targeting human podoplanin suppresses pulmonary metastasis via ADCC and CDC rather than via its neutralizing activity.2015

    • Author(s)
      Kato Y, Kunita A, Abe S, Ogasawara S, Fujii Y, Oki H, Fukayama M, Nishioka Y, Kaneko MK.
    • Journal Title

      Oncotarget.

      Volume: 6(34) Issue: 34 Pages: 36003-36018

    • DOI

      10.18632/oncotarget.5339

    • NAID

      120007120171

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Update on Epstein-Barr virus and gastric cancer (Review).2015

    • Author(s)
      Shinozaki-Ushiku A, Kunita A, Fukayama M.
    • Journal Title

      Int J Oncol

      Volume: 46 Issue: 4 Pages: 1421-1434

    • DOI

      10.3892/ijo.2015.2856

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Profiling of virus-encoded mcroRNAs in Epstein-Barr virus-associated gastric carcinoma and their roles in gastric carcinogenesis.2015

    • Author(s)
      Shinozaki-Ushiku A, Kunita A, Isogai M, Hibiya T, Ushiku T, Takada K, and Fukayama M
    • Journal Title

      J Virol

      Volume: 89 Issue: 10 Pages: 5581-5591

    • DOI

      10.1128/jvi.03639-14

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hunner-Type (Classic) Interstitial Cystitis: A Distinct Inflammatory Disorder Characterized by Pancystitis, with Frequent Expansion of Clonal B-Cells and Epithelial Denudation.2015

    • Author(s)
      Maeda D, Akiyama Y, Morikawa T, Kunita A, Ota Y, Katoh H, Niimi A, Nomiya A, Ishikawa S, Goto A, Igawa Y, Fukayama M, Homma Y.
    • Journal Title

      PLos One

      Volume: 10 Issue: 11 Pages: 1-16

    • DOI

      10.1371/journal.pone.0143316

    • NAID

      120007089047

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The niche component periostin is produced by cancer-associated fibroblasts, supporting growth of gastric cancer through ERK activation2014

    • Author(s)
      Kikuchi Y, Kunita A, Iwata C, Komura D, Nishiyama T, Shimazu K, Takeshita K, Shibahara J, Kii I, Morishita Y, Yashiro M, Hirakawa K, Miyazono K, Kudo A, Fukayama M, Kashima TG.
    • Journal Title

      Am J Pathol.

      Volume: 184 Issue: 3 Pages: 859

    • DOI

      10.1016/j.ajpath.2013.11.012

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] HER2 protein overexpression and gene amplification in upper urinary tract urothelial carcinoma-an analysis of 171 patients2014

    • Author(s)
      asaki, Y, Sasaki, T, Kawai, T, Morikawa, T, Matsusaka, K, Kunita, A., Kume, H, Aoki, I, Homma, Y, and Fukayama, M.
    • Journal Title

      International Journal of Clinical and Experimental Pathology

      Volume: 7 Pages: 699-708

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] VEGF-Mediated Angiogenesis Links EMT-Induced Cancer Stemness to Tumor Initiation.2014

    • Author(s)
      Fantozzi, A, Gruber, D. C, Pisarsky, L, Heck, C, Kunita, A, Yilmaz, M, Meyer-Schaller, N, Cornille, K, Hopfer, U, Bentires-Alj, M, and Christofori, G.
    • Journal Title

      Cancer Research

      Volume: 74 Issue: 5 Pages: 1566-1575

    • DOI

      10.1158/0008-5472.can-13-1641

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis.2014

    • Author(s)
      Tanaka M, Suzuki HI, Shibahara J, Kunita A, Isagawa T, Yoshimi A, Kurokawa M, Miyazono K, Aburatani H, Ishikawa S, Fukayama M.
    • Journal Title

      Oncogene

      Volume: 33(19) Issue: 19 Pages: 2454-63

    • DOI

      10.1038/onc.2013.204

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 新規抗ポドプラニンキメラ抗体による抗腫瘍効果の検討2015

    • Author(s)
      国田朱子、 小笠原諭、金子美華、加藤幸成
    • Organizer
      第38回日本分子生物学会年会・第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス胃癌モデルを用いたLMP2Aの機能解析2015

    • Author(s)
      国田朱子、市村香代子、沼倉里枝、日比谷孝志、坂谷貴司、大島正伸 、深山正久
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規抗ポドプラニンキメラ抗体による転移抑制効果の検討2015

    • Author(s)
      国田 朱子、加藤 幸成、大木 弘治、西岡 安彦、深山 正久
    • Organizer
      第24回日本がん転移学会学術集会総会
    • Place of Presentation
      シティプラザ大阪(大阪府中央区)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Epstein-Barr Virus-encoded MicroRNAs in Gastric Carcinoma2015

    • Author(s)
      国田朱子、牛久 綾、 阿部浩幸、 日向宗利、深山正久
    • Organizer
      第5回新学術領域発がんスパイラル国際シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2015-02-26 – 2015-02-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Identification of Interleukin 13 Receptor alpha 2 (IL13Rα2) as a novel marker of human melanoma2015

    • Author(s)
      Mao Komai, Akiko Kunita, Teppei Morikawa, Hayato Okamoto1, Moegi Sato1, Hiroaki Uchida1, Yasuhiro Yoshimatsu1, Takeshi Fukuhara, Masashi Fukayama, Tetsuro Watabe
    • Organizer
      Joint International Symposium on TGF-B Family and Cancer
    • Place of Presentation
      筑波
    • Year and Date
      2015-01-12 – 2015-01-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Leptin receptor expression and loss of SOCS3 in Epstein-Barr virus –associated gastric carcinoma (EBVaGC).2014

    • Author(s)
      国田朱子,日野るみ、阿部浩幸、深山正久
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] EBウイルス関連胃癌におけるウイルス由来マイクロRNAの特性解析2014

    • Author(s)
      国田朱子,阿部浩幸、日向宗利、牛久綾、深山正久
    • Organizer
      第6回日本RNAi研究会
    • Place of Presentation
      広島
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺腺癌腫瘍間質におけるmiR-21の発現2014

    • Author(s)
      国田朱子、森田茂樹、深山正久
    • Organizer
      第33回分子病理学研究会宮城蔵王シンポジウム
    • Place of Presentation
      宮城蔵王
    • Year and Date
      2014-07-25 – 2014-07-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Expression of miR-21 in cancer associated fibroblasts in lung adenocarcinoma2014

    • Author(s)
      Akiko Kunita, Shigeki Morita, Masashi Fukayama
    • Organizer
      AACR Annual Meeting 2014
    • Place of Presentation
      米国 サンディエゴ
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 腫瘍浸潤先端部におけるポドプラニンの発現解析2013

    • Author(s)
      国田朱子,深山正久
    • Organizer
      がん若手ワークショップ
    • Place of Presentation
      蓼科
    • Related Report
      2013 Research-status Report
  • [Presentation] Podoplanin expression at the tumor invasive front2013

    • Author(s)
      Akiko Kunita, Masashi Fukayama
    • Organizer
      AACR International Conference on Frontiers in Basic Cancer Research
    • Place of Presentation
      米国、ナショナルハーバー
    • Related Report
      2013 Research-status Report
  • [Presentation] 腫瘍浸潤先端部におけるpodoplaninの発現2013

    • Author(s)
      国田朱子,深山正久
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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