Functional analyses of Twist-1 in malignant mesothelioma using animal carcinogensis model.
Project/Area Number |
25860292
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
|
Research Institution | Nagoya University |
Principal Investigator |
OKAZAKI YASUMASA 名古屋大学, 医学(系)研究科(研究院), 講師 (30403489)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 中皮腫 / Twist-1 / 鉄 / 酸化ストレス / microRNA / 転写因子 / 腹膜中皮腫 |
Outline of Final Research Achievements |
With the aid of this grant, Twist-1 is also detected in carbon nanotubes (CNT)-induced SM. The expression of Twist-1 was not significantly affected the life span in asbestos and CNT-induced rat MM. The expression of MDM2, which is induced by Twist-1 and works to degradate p53, and Ki67, which is a marker for cellular proliferation, were associated with Twist-1 expression. These results suggest that Twist-1 has potent proliferative effect on MM in vivo. The examination for the expression of transcriptional factors, which are reported to be a candidate for the induction of Twist-1, disclosed the relation between Twist-1 and HIF1alpha expression in CNT-induced rat MM.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules2014
Author(s)
Yasumasa Okazaki, Yue Wang, Hiromasa Tanaka, Masaaki Mizuno, Kae Nakamura, Hiroaki Kajiyama, Hiroyuki Kano, Koji Uchida, Fumitaka Kikkawa, Masaru Hori, Shinya Toyokuni
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 55
Issue: 3
Pages: 207-215
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed / Open Access
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[Journal Article] Plasma Medical Science for Cancer Therapy: Toward Cancer Therapy Using Nonthermal Atmospheric Pressure Plasma2014
Author(s)
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Keigo Takeda, Kae Nakamura, Fumi Utsumi, Hiroaki Kajiyama, Hiroyuki Kano, Yasumasa Okazaki, Shinnya Toyokuni,Shoichi Maruyama, Fumitaka Kikkawa, Masaru Hori
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Journal Title
IEEE TRANSACTIONS ON PLASMA SCIENCE
Volume: 42
Issue: 12
Pages: 3760-3764
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production2013
Author(s)
S. H. Chew, Y. Okazaki, H. Nagai, N. Misawa, S. Akatsuka, K. Yamashita, L. Jiang, Y. Yamashita, M. Noguchi, K. Hosoda, Y. Sekido, T. Takahashi, S. Toyokuni
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Journal Title
Carcinogenesis
Volume: 35(1)
Issue: 1
Pages: 164-172
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] NON-EQUILIBRIUM ATMOSPHERIC PRESSURE PLASMA (NEAPP) GENERATES OXIDATIVE INJURY2015
Author(s)
Okazaki Y, Wang Y, Tanaka H, Mizuno M, Nakamura K, Kajiyama H, Kano H, Uchida K, Kikkawa F, Hori M,Toyokuni S
Organizer
IWPCT-2 (International Workshop on Plasma for Cancer Treatment-2)
Place of Presentation
名古屋大学(愛知県名古屋市)
Year and Date
2015-03-16 – 2015-03-17
Related Report
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[Presentation] 非平衡大気圧プラズマは酸化ストレスを生じる2014
Author(s)
岡崎泰昌, 王越, 田中宏昌, 水野正明, 中村香江, 梶山広明, 加納浩之, 内田浩二, 吉川史隆, 堀勝, 豊國伸哉
Organizer
第38回日本鉄バイオサイエンス学会学術集会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2014-09-06 – 2014-09-07
Related Report
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[Presentation] 非平衡大気圧プラズマは酸化ストレスを生じる2014
Author(s)
岡崎泰昌, 王越, 田中宏昌, 水野正明, 中村香江, 梶山広明, 加納浩之, 内田浩二, 吉川史隆, 堀勝, 豊國伸哉
Organizer
第67回日本酸化ストレス学会学術集会
Place of Presentation
同志社大学(京都府京都市)
Year and Date
2014-09-04 – 2014-09-05
Related Report
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[Presentation] 非平衡大気圧プラズマは酸化ストレスを生じる2014
Author(s)
岡崎泰昌, 王越, 田中宏昌, 水野正明, 中村香江, 梶山広明, 加納浩之, 内田浩二, 吉川史隆, 堀勝, 豊國伸哉
Organizer
第11回病理学会カンファレンス
Place of Presentation
六甲山ホテル(兵庫県神戸市)
Year and Date
2014-08-01 – 2014-08-02
Related Report
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[Book] 活性酸素の本当の姿2013
Author(s)
藤原 範子 (著), 大河原知水 (著), 木崎 節子 (著), 李 昌一 (著), 住本 英樹 (著), 赤池 孝章 (著), 藤井 重元 (著), 岡崎 泰昌 (著), 豊國 伸哉 (著), 内藤 裕二 (著), 大野 秀樹 (著), 鈴木敬一郎 (編集)
Total Pages
176
Publisher
ナップ
Related Report