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Functional analyses of Twist-1 in malignant mesothelioma using animal carcinogensis model.

Research Project

Project/Area Number 25860292
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionNagoya University

Principal Investigator

OKAZAKI YASUMASA  名古屋大学, 医学(系)研究科(研究院), 講師 (30403489)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords中皮腫 / Twist-1 / 鉄 / 酸化ストレス / microRNA / 転写因子 / 腹膜中皮腫
Outline of Final Research Achievements

With the aid of this grant, Twist-1 is also detected in carbon nanotubes (CNT)-induced SM. The expression of Twist-1 was not significantly affected the life span in asbestos and CNT-induced rat MM. The expression of MDM2, which is induced by Twist-1 and works to degradate p53, and Ki67, which is a marker for cellular proliferation, were associated with Twist-1 expression. These results suggest that Twist-1 has potent proliferative effect on MM in vivo. The examination for the expression of transcriptional factors, which are reported to be a candidate for the induction of Twist-1, disclosed the relation between Twist-1 and HIF1alpha expression in CNT-induced rat MM.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (20 results)

All 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (11 results) Book (3 results)

  • [Journal Article] Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules2014

    • Author(s)
      Yasumasa Okazaki, Yue Wang, Hiromasa Tanaka, Masaaki Mizuno, Kae Nakamura, Hiroaki Kajiyama, Hiroyuki Kano, Koji Uchida, Fumitaka Kikkawa, Masaru Hori, Shinya Toyokuni
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 55 Issue: 3 Pages: 207-215

    • DOI

      10.3164/jcbn.14-40

    • NAID

      130004687669

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rat model demonstrates a high risk of tremolite but a low risk of anthophyllite for mesothelial carcinogenesis2014

    • Author(s)
      Aierken D, Okazaki Y, Chew SH, Sakai A, Wang Y, Nagai H, Misawa N, Kohyama N, Toyokuni S
    • Journal Title

      Nagoya J Med Sci

      Volume: 76(1-2) Pages: 149-160

    • NAID

      120005385259

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma Medical Science for Cancer Therapy: Toward Cancer Therapy Using Nonthermal Atmospheric Pressure Plasma2014

    • Author(s)
      Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Keigo Takeda, Kae Nakamura, Fumi Utsumi, Hiroaki Kajiyama, Hiroyuki Kano, Yasumasa Okazaki, Shinnya Toyokuni,Shoichi Maruyama, Fumitaka Kikkawa, Masaru Hori
    • Journal Title

      IEEE TRANSACTIONS ON PLASMA SCIENCE

      Volume: 42 Issue: 12 Pages: 3760-3764

    • DOI

      10.1109/tps.2014.2353659

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production2013

    • Author(s)
      S. H. Chew, Y. Okazaki, H. Nagai, N. Misawa, S. Akatsuka, K. Yamashita, L. Jiang, Y. Yamashita, M. Noguchi, K. Hosoda, Y. Sekido, T. Takahashi, S. Toyokuni
    • Journal Title

      Carcinogenesis

      Volume: 35(1) Issue: 1 Pages: 164-172

    • DOI

      10.1093/carcin/bgt267

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deferasirox induces mesenchymal-epithelial transition in crocidolite-induced mesothelila carcinogenesis in rats.2013

    • Author(s)
      Nagai H, Okazaki Y, Chew SH, Misawa N, Yasui H and Toyokuni S.
    • Journal Title

      Cance Prev Res.

      Volume: 6 Issue: 11 Pages: 1222-1230

    • DOI

      10.1158/1940-6207.capr-13-0244

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] “Intraperitoreal Administration of Tangled Multiwall Carbon Nanotubes of 15 nm in Diameter Does Not Induce Mesothelial Carcinogenesis in Rats”2013

    • Author(s)
      H.Nagai
    • Journal Title

      Pathology International

      Volume: 63 Issue: 9 Pages: 457-462

    • DOI

      10.1111/pin.12093

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] NON-EQUILIBRIUM ATMOSPHERIC PRESSURE PLASMA (NEAPP) GENERATES OXIDATIVE INJURY2015

    • Author(s)
      Okazaki Y, Wang Y, Tanaka H, Mizuno M, Nakamura K, Kajiyama H, Kano H, Uchida K, Kikkawa F, Hori M,Toyokuni S
    • Organizer
      IWPCT-2 (International Workshop on Plasma for Cancer Treatment-2)
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2015-03-16 – 2015-03-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Non-equilibrium atmospheric pressure plasma (NEAPP) generates oxidative injury2014

    • Author(s)
      Okazaki Y, Wang Y, Tanaka H, Mizuno M, Nakamura K, Kajiyama H, Kano H, Kikkawa F, Hori M,Toyokuni S
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非平衡大気圧プラズマは酸化ストレスを生じる2014

    • Author(s)
      岡崎泰昌, 王越, 田中宏昌, 水野正明, 中村香江, 梶山広明, 加納浩之, 内田浩二, 吉川史隆, 堀勝, 豊國伸哉
    • Organizer
      第38回日本鉄バイオサイエンス学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-09-06 – 2014-09-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非平衡大気圧プラズマは酸化ストレスを生じる2014

    • Author(s)
      岡崎泰昌, 王越, 田中宏昌, 水野正明, 中村香江, 梶山広明, 加納浩之, 内田浩二, 吉川史隆, 堀勝, 豊國伸哉
    • Organizer
      第67回日本酸化ストレス学会学術集会
    • Place of Presentation
      同志社大学(京都府京都市)
    • Year and Date
      2014-09-04 – 2014-09-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非平衡大気圧プラズマは酸化ストレスを生じる2014

    • Author(s)
      岡崎泰昌, 王越, 田中宏昌, 水野正明, 中村香江, 梶山広明, 加納浩之, 内田浩二, 吉川史隆, 堀勝, 豊國伸哉
    • Organizer
      第11回病理学会カンファレンス
    • Place of Presentation
      六甲山ホテル(兵庫県神戸市)
    • Year and Date
      2014-08-01 – 2014-08-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] Non-equilibrium atmospheric pressure plasma (NEAPP) generates oxidative injury2014

    • Author(s)
      Okazaki Y, Wang Y, Tanaka H, Mizuno M, Nakamura K, Kajiyama H, Kano H, Kikkawa F, Hori M,Toyokuni S
    • Organizer
      ICPM-5 (International Conference on Plasma Medicine-5)
    • Place of Presentation
      奈良県立公会堂(奈良県奈良市)
    • Year and Date
      2014-05-18 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Non-equilibrium atmospheric pressure plasma (NEAPP) generates oxidative injury2014

    • Author(s)
      Yasumasa Okazaki, Yue Wang, Hiromasa Tanaka, Masaaki Mizuno, Kae Nakamura, Hiroaki Kajiyama, Hiroyuki Kano, Fumitaka Kikkawa, Masaru Hori, Shinya Toyokuni
    • Organizer
      Society for Free Radical Research International 2014
    • Place of Presentation
      京都国際会議場(京都市)
    • Related Report
      2013 Research-status Report
  • [Presentation] DAP (DMT1 ASSOCIATED PROTEIN) REGULATES CELL PROLIFERATION THROUGH THE REGULATION OF DMT1 (IRE)2013

    • Author(s)
      Yasumasa Okazaki, Hirotaka Nagai, Satomi Funahashi, Shan-Hwu Chew, Mary Yeh, Kwo-yih Yeh, Jonathan Glass, Shinya Toyokuni
    • Organizer
      Biennial meeting of Society for Free Radical Research-Asia
    • Place of Presentation
      台北(台湾)
    • Related Report
      2013 Research-status Report
  • [Presentation] CD146、IMP3の過剰発現はアスベスト誘発ラット悪性腹膜中皮腫の生存期間を短縮する2013

    • Author(s)
      岡崎泰昌、永井裕崇、周珊瑚、蒋麗、舟橋諭美、辻村亨、豊國伸哉
    • Organizer
      第37回日本鉄バイオサイエンス学会学術集会
    • Place of Presentation
      JA共済ビル(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] CD146、IMP3の過剰発現はアスベスト誘発ラット悪性腹膜中皮腫の生存期間を短縮する2013

    • Author(s)
      岡崎泰昌、永井裕崇、周珊瑚、蒋麗、舟橋諭美、辻村亨、豊國伸哉
    • Organizer
      第66回日本酸化ストレス学会
    • Place of Presentation
      ウインク愛知(名古屋市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 実験病理学分野における若手研究者のアメリカ留学の一例2013

    • Author(s)
      岡崎泰昌
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2013 Research-status Report
  • [Book] ロビンス 基礎病理学 原書9版2014

    • Author(s)
      (分担翻訳)岡崎泰昌
    • Total Pages
      1087
    • Publisher
      丸善出版、エルゼビア ジャパン
    • Related Report
      2014 Annual Research Report
  • [Book] 改訂第二版 酸化ストレスの医学2014

    • Author(s)
      (分担執筆)岡崎泰昌, et al.
    • Total Pages
      444
    • Publisher
      診断と治療社
    • Related Report
      2014 Annual Research Report
  • [Book] 活性酸素の本当の姿2013

    • Author(s)
      藤原 範子 (著), 大河原知水 (著), 木崎 節子 (著), 李 昌一 (著), 住本 英樹 (著), 赤池 孝章 (著), 藤井 重元 (著), 岡崎 泰昌 (著), 豊國 伸哉 (著), 内藤 裕二 (著), 大野 秀樹 (著), 鈴木敬一郎 (編集)
    • Total Pages
      176
    • Publisher
      ナップ
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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