| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, immunohistochemical analysis revealed CD109 expression in human and murine osteoclasts in bones and osteoclast-like multinucleated giant cells in human osteosarcoma and giant cell tumor.
In addition, we performed co-culture experiments using primary osteoblasts and pre-osteoclasts isolated from either wild-type or CD109-deficient mice. In this in vitro co-culture experiments, CD109-deficient pre-osteoclasts failed to multinucleate by cell fusion.
These findings suggest that CD109 plays a role in cell fusion of osteoclasts and in formation of osteoclast-like multinucleated giant cells.
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