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Investigation of new therapeutic target against influenza virus infection

Research Project

Project/Area Number 25860296
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionNara Medical University (2014)
Okayama University (2013)

Principal Investigator

ITO TOSHIHIRO  奈良県立医科大学, 医学部, 教授 (00595712)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsエピジェネティクス / インフルエンザウィルス / 気道上皮細胞 / マクロファージ / ヒストンメチル化
Outline of Final Research Achievements

Influenza A virus causes acute respiratory infections that induce annual epidemics and occasional pandemics. Especially, the main cause of death in influenza viral infection is secondary bacterial pneumonia. Both bronchial epithelial cells and macrophages upregulated SET domain, bifurcated 2 (SETDB2) expression following influenza virus H1N1 infection. SETDB2 is a histone methyltransferase that methylates Lys-9 of histone H3 (H3K9), which is correlated with repression of transcription. SETDB2 expression is dependent on RIG-I induced type-I IFN pathway. Moreover, SETDB2 regulates TRAF2, an adaptor molecule of TNF signaling, and amphiregulin, which plays a critical role for promoting the restoration of airway epithelial integrity and lung tissue homeostasis.
These findings indicate that SETDB2 regulation might be one of the critical therapeutic target for influenza virus infection and secondary bacterial pneumonia.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (4 results)

  • [Journal Article] Spred-2 deficiency exacerbates lipopolysaccharide-induced acute lung inflammation in mice2014

    • Author(s)
      Xu Y, Ito T, Fushimi S, Takahashi S, Itakura J, Kimura R, Sato M, Mino M, Yoshimura A, Matsukawa A
    • Journal Title

      PLoS One

      Volume: 9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The in vivo fibrotic role of FIZZ1 in pulmonary fibrosis2014

    • Author(s)
      Liu T, Yu H, Ullenbruch M, Jin H, Ito T, Wu Z, Liu J, Phan SH.
    • Journal Title

      PLoS One

      Volume: 9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The in vivo fibrotic role of FIZZ1 in pulmonary fibrosis2014

    • Author(s)
      Liu T, Yu H, Ullenbruch M, Jin H, Ito T, Wu Z, Liu J, Phan SH
    • Journal Title

      PLoS One

      Volume: 9 Issue: 2 Pages: e88362-e88362

    • DOI

      10.1371/journal.pone.0088362

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] T helper 2 and regulatory T cell cytokine production by mast cells: A key factor in the pathogenesis of IgG4-related disease.2014

    • Author(s)
      Takeuchi, M., Sato, Y., Ohno, K., Tanaka, S., Takata, K., Gion, Y., Orita,Y., Ito, T., Tachibana, T. and Yoshino, T.
    • Journal Title

      Mod. Pathol.

      Volume: 27 Issue: 8 Pages: 1126-1136

    • DOI

      10.1038/modpathol.2013.236

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] MHV68 Latency Modulates the Host Immune Response to Influenza A Virus2013

    • Author(s)
      Saito F, Ito T, Connett JM, Schaller MA, Carson WF 4th, Hogaboam CM, Rochford R, Kunkel SL
    • Journal Title

      Inflammation

      Volume: 36 Issue: 6 Pages: 1295-1303

    • DOI

      10.1007/s10753-013-9668-1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinicopathologic analysis of IgG4-related skin disease.2013

    • Author(s)
      Sato Y, Takeuchi M, Takata K, Ohno K, Iwaki N, Orita Y, Goto N, Hida AI, Iwamoto T, Asano N, Ito T, Hanakawa H, Yanai H, Yoshino T.
    • Journal Title

      Mod Pathol.

      Volume: 26 Issue: 4 Pages: 523-532

    • DOI

      10.1038/modpathol.2012.196

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cutting needle biopsy combined with immunohistochemical study of myeloperoxidase for the diagnosis of histiocytic necrotizing lymphadenitis2013

    • Author(s)
      Hanakawa H, Orita Y, Sato Y, Takeuchi M, Ohno K, Iwaki N, Ito T, Nishizaki K, Yoshino T
    • Journal Title

      Acta oto-laryngologica

      Volume: 133 Issue: 12 Pages: 1328-1332

    • DOI

      10.3109/00016489.2013.824112

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells2013

    • Author(s)
      Yoshimura T, Howard OM, Ito T, Kuwabara M, Matsukawa A, Chen K, Liu Y, Liu M, Oppenheim JJ, Wang JM
    • Journal Title

      PLoS One

      Volume: 8 Issue: 3 Pages: e58791-e58791

    • DOI

      10.1371/journal.pone.0058791

    • NAID

      120005703799

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] The critical role of epigenetic regulation against secondary bacterial pneumonia following influenza virus infection2014

    • Author(s)
      Toshihiro Ito, Steven L. Kunkel, Akihiro Matsukawa
    • Organizer
      The 13th Awaji International Forum on Infection and Immunity in Nara
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2014-09-23 – 2014-09-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Spred-2 deficiency exacebates Influenza A Virus (H1N1)-induced Pneumonia2013

    • Author(s)
      Toshihiro Ito, Akihiko Yoshimura, and Akihiro Matsukawa
    • Organizer
      15th International Congress of Immunology
    • Place of Presentation
      ミラノ(イタリア)
    • Related Report
      2013 Research-status Report
  • [Presentation] Epigenetic regulation of secondary bacterial pneumonia following influenza virus infection2013

    • Author(s)
      ITO Toshihiro, KUNKEL L. Steven, MATSUKAWA Akihiro
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      千葉市
    • Related Report
      2013 Research-status Report
  • [Presentation] T細胞Suppressor of Cytokine Signaling 5 (SOCS5)の過剰発現はLPSトレランス効果を増強する2013

    • Author(s)
      伊藤利洋、板倉淳哉、佐藤美和、美野愛、伏見聡一郎、松川昭博
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌市
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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