|Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|Outline of Final Research Achievements
Transcription factor, FoxO1 and FoxO3a, may regulate anti-neoplastic effect and lifespan extension effect of calorie restriction (CR), respectively. However, most of target genes of FoxO1 and FoxO3a are common, and the mechanisms that the specific target genes are regulated by each FoxOs are unknown. In this study, we identified the anti-neoplastic effect related genes and the lifespan extension effect related genes using microarray analysis that were regulated by FoxO1 and FoxO3a, respectively. Especially, FoxO3a knock down affected to the expression of mitochondria related genes. Actually, isolated mitochondria from FoxO3a KO mice under CR showed abnormal activity compared with the mitochondria from the wild type-CR mice. These results suggest that the regulation of mitochondria function by FoxO3a, not FoxO1, might be important for CR induced lifespan extension effect.