Analysis of chondroclasts in rheumatoid arthritis
Project/Area Number |
25860299
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | Iwate Medical University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 炎症 / 関節リウマチ |
Outline of Final Research Achievements |
The aim of this study is to reveal the character of chondroclasts in rheumatoid arthritis (RA), so-called from the location near cartilage. The analysis using tissue from RA patients revealed that chondroclasts produce the enzymes which degrade extra cellular matrix of cartilage. The analysis of cultured cells revealed that a particular cytokine induce the differentiation into chondroclasts. Thus, it is suggested that chondroclasts are involved in cartilage degradation and joint destruction in RA patients.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] World’s first telepathology experiments employing ultra-high-speed internet satellite, nickenemaed “KIZUNA”.2013
Author(s)
Sawai T, Uzuki M, Miura Y, Kamataki A, Matsumura T, Saito K, Kurose A, Osamura YR, Yoshimi N, Kanno H, Moriya T, Ishida Y, Satoh Y, Nakao M, Ogawa E, Matsuo S, Kasai H, Kumagai K, Motoda T, Hopson N
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Journal Title
J Pathol Inform
Volume: 4
Issue: 1
Pages: 24-24
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serial block-face scanning electron microscopy combined with double-axis electron beam tomography provides new insight into cellular relationships2013
Author(s)
Sawai T, Kamataki A, Uzuki M, Ishida K, Hanasaka T, Ochi K, Hashimoto T, Kubo T, Morikawa A, Ochi T, Tohyama K
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Journal Title
Microscopy (Oxf)
Volume: 62
Issue: 2
Pages: 317-320
DOI
Related Report
Peer Reviewed
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