Identification of the determinants of susceptibility to high-fat diet-induced glucose intolerance using a new mouse model
| Project/Area Number |
25860300
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Research Collaborator |
YAGIHASHI Souroku
INABA Wataru
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 選抜交配 / モデルマウス / 高脂肪食 / 耐糖能異常 / 摂食行動 / インスリン分泌能 / レプチン分泌能 / 糖尿病 / 糖尿病モデルマウス |
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| Outline of Final Research Achievements |
We have performed repetitive selective breeding of mice exhibiting different glucose tolerance after high-fat diet (HFD) feeding, and recently established 2 mouse lines with distinctively different susceptibilities (prone and resistant) to HFD-induced glucose intolerance (SDG-P and SDG-R, respectively). In the present study, we analyzed the differences in insulin secretory capacity and in feeding behavior between the 2 lines of mice to explore the hereditary predisposition to HFD-induced glucose intolerance. As compared to SDG-R mice, SDG-P mice showed lower glucose-induced insulin secretory capacity in vivo and in vitro (isolated islets) even before HFD feeding. In addition, SDG-P mice showed hyperphagia preceding the development of obesity under HFD feeding, and had lower plasma leptin levels as compared to SDG-R mice. In conclusion, hereditary insulin and leptin secretion may determine the susceptibility to HFD-induced glucose intolerance.
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Report
(3 results)
Research Products
(26 results)
