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Identification of the determinants of susceptibility to high-fat diet-induced glucose intolerance using a new mouse model

Research Project

Project/Area Number 25860300
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionNippon Medical School

Principal Investigator

NAGAO Mototsugu  日本医科大学, 医学部, 助教 (10468762)

Research Collaborator YAGIHASHI Souroku  
INABA Wataru  
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords選抜交配 / モデルマウス / 高脂肪食 / 耐糖能異常 / 摂食行動 / インスリン分泌能 / レプチン分泌能 / 糖尿病 / 糖尿病モデルマウス
Outline of Final Research Achievements

We have performed repetitive selective breeding of mice exhibiting different glucose tolerance after high-fat diet (HFD) feeding, and recently established 2 mouse lines with distinctively different susceptibilities (prone and resistant) to HFD-induced glucose intolerance (SDG-P and SDG-R, respectively). In the present study, we analyzed the differences in insulin secretory capacity and in feeding behavior between the 2 lines of mice to explore the hereditary predisposition to HFD-induced glucose intolerance. As compared to SDG-R mice, SDG-P mice showed lower glucose-induced insulin secretory capacity in vivo and in vitro (isolated islets) even before HFD feeding. In addition, SDG-P mice showed hyperphagia preceding the development of obesity under HFD feeding, and had lower plasma leptin levels as compared to SDG-R mice. In conclusion, hereditary insulin and leptin secretion may determine the susceptibility to HFD-induced glucose intolerance.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (26 results)

All 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (20 results) (of which Invited: 3 results)

  • [Journal Article] Transgenerational changes of metabolic phenotypes in two selectively bred mouse colonies for different susceptibilities to diet-induced glucose intolerance2015

    • Author(s)
      Nagao M, Asai A, Sugihara H, Oikawa S
    • Journal Title

      Endocrine Journal

      Volume: 62 Issue: 4 Pages: 371-378

    • DOI

      10.1507/endocrj.EJ14-0241

    • NAID

      130005066937

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 脂肪摂取と2型糖尿病2015

    • Author(s)
      長尾元嗣, 浅井明, 杉原仁, 及川眞一
    • Journal Title

      オレオサイエンス

      Volume: 15 Pages: 69-78

    • NAID

      130006329110

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 高血糖と動脈硬化 実験動物からのアプローチ2014

    • Author(s)
      長尾元嗣, 浅井明, 及川眞一
    • Journal Title

      糖尿病合併症

      Volume: 28 Pages: 66-69

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Characterization of pancreatic islets in two selectively bred mouse lines with different susceptibilities to high-fat diet-induced glucose intolerance.2014

    • Author(s)
      Nagao M, Asai A, Inaba W, Kawahara M, Shuto Y, Kobayashi S, Sanoyama D, Sugihara H, Yagihashi S, Oikawa S
    • Journal Title

      PLoS One

      Volume: 9 Issue: 1 Pages: e84725-e84725

    • DOI

      10.1371/journal.pone.0084725

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of impaired glucose tolerance on atherosclerotic lesion formation: an evaluation in selectively bred mice with different susceptibilities to glucose intolerance2013

    • Author(s)
      Asai A, Nagao M, Kawahara M, Shuto Y, Sugihara H, Oikawa S
    • Journal Title

      Atherosclerosis

      Volume: 231 Issue: 2 Pages: 421-426

    • DOI

      10.1016/j.atherosclerosis.2013.10.009

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] メタボリックシンドロームにおける疾患感受性規定因子の解明-新規モデルマウスを用いた解析-2013

    • Author(s)
      長尾元嗣、浅井明、杉原仁、及川眞一
    • Journal Title

      Therapeutic Research

      Volume: 34 Pages: 931-935

    • Related Report
      2013 Research-status Report
  • [Presentation] 高脂肪食誘発生耐糖能異常への感受性が異なる2系統のマウスにおけるレプチン分泌と視床下部レプチン受容体に関する解析2014

    • Author(s)
      長尾元嗣、浅井明、杉原仁、及川眞一
    • Organizer
      第41回日本神経内分泌学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高脂肪食誘発生肥満耐糖能異常マウスと同抵抗性マウスのレプチン分泌動態に関する解析2014

    • Author(s)
      長尾元嗣、浅井明、小林俊介、周東佑樹、真山大輔、杉原仁、及川眞一
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Transgenerational phenotypic changes in selectively bred mice for different susceptibilities to diet-induced glucose intolerance2014

    • Author(s)
      Nagao M, Asai A, Sugihara H, Oikawa S
    • Organizer
      50th EASD (Annual Meeting of the European Association for the Study of Diabetes)
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2014-09-15 – 2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Gene-Environment Interactionに基づいた新しい糖尿病モデルマウスの開発とその解析2014

    • Author(s)
      長尾元嗣
    • Organizer
      第82回日本医科大学医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 高脂肪食誘導性耐糖異常への感受性が異なるSDG-P/Rマウスのインスリン分泌能と膵臓遺伝子発現に関する解析2014

    • Author(s)
      長尾元嗣、浅井明、真山大輔、周東佑樹、小林俊介、杉原仁、及川眞一
    • Organizer
      第46回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 遺伝的な膵島機能によって規定される高脂肪食誘導性耐糖能異常の出現:新規選抜交配モデルマウスでの解析2014

    • Author(s)
      長尾元嗣、浅井明、稲葉渉、小林俊介、周東佑樹、真山大輔、杉原仁、八木橋操六、及川眞一
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 耐糖能と摂食行動の遺伝的な差異が寿命に及ぼす影響:新規選抜交配モデルマウスでの解析2014

    • Author(s)
      真山大輔、長尾元嗣、浅井明、周東佑樹、小林俊介、杉原仁、及川眞一
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高脂肪食誘導性耐糖能異常への感受性が異なる新規選抜交配モデルマウスのインスリン分泌能に関する解析2014

    • Author(s)
      長尾元嗣、浅井明、周東佑樹、杉原仁、及川眞一
    • Organizer
      第28回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Research-status Report
  • [Presentation] 高脂肪食誘導性耐糖能異常への感受性が異なる新規選抜交配モデルマウスにおける動脈硬化巣形成に関する解析2014

    • Author(s)
      周東佑樹、浅井明、長尾元嗣、杉原仁、及川眞一
    • Organizer
      第28回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Research-status Report
  • [Presentation] 高脂肪食による体重増加や耐糖能異常の発症を規定する遺伝的要因の解析:マウスを用いた長期選抜交配からの考察2013

    • Author(s)
      長尾元嗣、浅井明、杉原仁、及川眞一
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 高脂肪食に対する耐糖能異常の感受性が異なる新規選抜交配モデルマウスの単離膵島に関する解析2013

    • Author(s)
      長尾元嗣、浅井明、川原百代、小林俊介、真山大輔、周東佑樹、原田太郎、稲垣恭子、杉原仁、及川眞一
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 高脂肪食に対する耐糖能異常の感受性を規定する遺伝的要因の考察:マウスを用いた長期選抜交配から2013

    • Author(s)
      小林俊介、長尾元嗣、浅井明、川原百代、真山大輔、周東佑樹、原田太郎、稲垣恭子、杉原仁、及川眞一
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report
  • [Presentation] 高脂肪食誘発性耐糖能異常に対する感受性の異なる2系統の選抜交配マウスにおける耐糖能・体重・摂餌量の世代間比較2013

    • Author(s)
      長尾元嗣、浅井明、周東佑樹、川原百代、小林俊介、真山大輔、杉原仁、及川眞一
    • Organizer
      第45回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 高脂肪食誘発性耐糖能異常に対する感受性の異なる2系統の選抜交配マウスにおける動脈硬化巣形成の選抜交配世代間比較2013

    • Author(s)
      周東佑樹、浅井明、長尾元嗣、川原百代、杉原仁、及川眞一
    • Organizer
      第45回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Impaired islet function and structure in mice with hereditary predisposition to high fat diet-induced glucose intolerance2013

    • Author(s)
      Nagao M, Asai A, Inaba W, Kawahara M, Sugihara H, Yagihashi S, Oikawa S
    • Organizer
      49th EASD Annual Meeting of the European Association for the Study of Diabetes
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Repetitive selective breeding for susceptibility to glucose intolerance accelerates atherosclerotic lesion formation in mice2013

    • Author(s)
      Asai A, Nagao M, Kawahara M, Sugihara H, Oikawa S
    • Organizer
      49th EASD Annual Meeting of the European Association for the Study of Diabetes
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] Feeding behavior as a hereditary predisposition to diet-induced glucose intolerance2013

    • Author(s)
      Nagao M, Asai A, Kobayashi S, Shuto Y, Sanoyama D, Harada T, Tanimura-Inagaki K, Sugihara H, Oikawa S
    • Organizer
      36th Naito Conference
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 高血糖と動脈硬化-実験動物からのアプローチ-2013

    • Author(s)
      長尾元嗣、浅井明、杉原仁、鈴木信也、永島和幸、及川眞一
    • Organizer
      第28回日本糖尿病合併症学会
    • Place of Presentation
      旭川
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Feeding behavior in mice with hereditary predisposition to high fat-diet induced glucose intolerance2013

    • Author(s)
      Nagao M, Asai A, Kobayashi S, Shuto Y, Sanoyama D, Sugihara H, Oikawa S
    • Organizer
      Asia-Pacific Diabetes and Obesity Study Group symposium 2013
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 高脂肪食誘発性耐糖能異常への感受性が異なる2系統のマウスにおける摂食行動の検討2013

    • Author(s)
      長尾元嗣、浅井明、杉原仁、及川眞一
    • Organizer
      第40回日本神経内分泌学会学術集会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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