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Molecular basis on the host range in the human malaria parasite Plasmodium vivax

Research Project

Project/Area Number 25860308
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Parasitology (including sanitary zoology)
Research InstitutionOsaka City University

Principal Investigator

TACHIBANA SHINICHIRO  大阪市立大学, 大学院理学研究科, 特任助教 (90414630)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords三日熱マラリア原虫 / サルマラリア原虫 / 感染能 / 宿主特異性 / DBP / Duffy抗原
Outline of Final Research Achievements

Plasmodium vivax, the human malaria parasite, is believed to become a parasite of man by host switch from a monkey malaria parasite that infects Asian Old World monkeys. It remains totally unknown why P. vivax infects only human and has lost their infectivity to monkeys. To elucidate the molecular basis of the host specificity, we investigated properties of the Duffy antigen that is a surface receptor on red blood cells in hosts and the Duffy-binding protein (DBP) that is a ligand for the Duffy antigen in the parasite, and identified putative amino acid changes related to the host specificity.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] Plasmodium vivax and Plasmodium falciparum at the Crossroads of Exchange among Islands in Vanuatu: Implications for Malaria Elimination Strategies.2015

    • Author(s)
      Chan CW, Sakihama N, Tachibana S, Lum JK, Tanabe K, Kaneko A.
    • Journal Title

      PloS One

      Volume: 10(3) Issue: 3 Pages: e0119475-e0119475

    • DOI

      10.1371/journal.pone.0119475

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Contrasting infection susceptibility of the Japanese macaques and cynomolgus macaques to closely related malaria parasites, Plasmodium vivax and Plasmodium cynomolgi.2014

    • Author(s)
      Tachibana SI, Kawai S, Katakai Y, Takahashi H, Nakade T, Yasutomi Y, Horii T, Tanabe K.
    • Journal Title

      Parasitol Int.

      Volume: S1383-5769 Issue: 3 Pages: 140-148

    • DOI

      10.1016/j.parint.2014.10.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristic age distribution of Plasmodium vivax infections after malaria elimination on Aneityum Island, Vanuatu2014

    • Author(s)
      Kaneko A, Chaves LF, Taleo G, Kalkoa M, Drakeley C, Bjorkman A, Troye-Blomberg M, Tachibana S-I, Tanabe K
    • Journal Title

      Infect Immun.

      Volume: 82 Issue: 1 Pages: 243-252

    • DOI

      10.1128/iai.00931-13

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasmodium falciparum mitochondrial genetic diversity exhibits isolation-by-distance patterns supporting a sub-Saharan African origin.2013

    • Author(s)
      Tanabe K, Jombart T, Horibe S, Palacpac N, Honma H, Tachibana S, Nakamura M, Horii T, Kishinod H, Mita T*.
    • Journal Title

      Mitochondrion

      Volume: 13 Issue: 6 Pages: 630-636

    • DOI

      10.1016/j.mito.2013.08.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] アジア旧世界サルが三日熱マラリア原虫の感染を回避する仕組みについて2015

    • Author(s)
      橘真一郎, 川合覚, 片貝祐子, 高橋英夫, 中出亮, 保富康宏, 堀井俊宏, 田邉和裄
    • Organizer
      第84回日本寄生虫学会大会
    • Place of Presentation
      杏林大学三鷹キャンパス(東京都三鷹市)
    • Year and Date
      2015-03-21 – 2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] サルマラリア原虫のゲノム解読によって明らかになった三日熱マラリア原虫の宿主特異性の分子基盤に関する手がかり

    • Author(s)
      橘真一郎, 田邉和裄
    • Organizer
      2013年日本動物学会近畿支部研究発表会
    • Place of Presentation
      大阪市立大学梅田サテライト(大阪市北区)
    • Related Report
      2013 Research-status Report
  • [Presentation] Plasmodium cynomolgi genome sequence provides clues to the host specificity of Plasmodium vivax and related monkey malaria parasites

    • Author(s)
      Tachibana S-I, Tanabe K
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 三日熱マラリア原虫のヒト特異的な感染の理解に向けた生化学的アプローチ

    • Author(s)
      橘真一郎, 川合覚, 塩田正之, 田中昌子, 東岸任弘, 田邉和裄
    • Organizer
      第11回分子寄生虫・マラリア研究フォーラム
    • Place of Presentation
      長崎大学医学部ポンペ会館(長崎県長崎市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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