| Project/Area Number |
25860313
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 黄色ブドウ球菌 / 形質転換 / コンピテンス / 薬剤耐性 / 自然形質転換 / シグマ因子 |
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| Outline of Final Research Achievements |
Staphylococcus aureus is a commensal bacterium living in our nasal cavities. It is also an important human pathogen, and has acquired a variety of virulence factors and antibiotics resistance genes through horizontal gene transfer.
In the present study, we focused on natural genetic competence. We succeeded in identification of factors that can sense environmental stimuli and control the expression of DNA incorporation machinery. We also succeeded in identification of growth conditions that increases transformation frequency. In addition, we found that some of the currently used antibiotics can affect the natural transformation. Thus, this study first clarified new aspects on the evolutionary ability by natural genetic competence in S. aureus.
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