Pathogenic analysis of S. aureus isolated from Staphylococcal Scaled skin syndrome
| Project/Area Number |
25860321
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Hiroshima University |
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Principal Investigator |
HISATSUNE Junzo 広島大学, 医歯薬保健学研究院, 助教 (40513180)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細菌 / ゲノム / タンパク質 / 微生物 / 蛋白質 / 進化 |
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| Outline of Final Research Achievements |
On the investigation A), we found that A domain of Skip deletion mutant strain was not digested by human serum and human plasmin. And then, we found that cutting site of Skip have about N terminus 20 amino acid in A domain of Skip.On the investigation B), highly expressing Skip strain lacked 6-nucleotides in internecine region of arT and sarU. We found that global regulator MgrA binds to the region containing 6-nucleotides and lack of the short stretch prevents the binding of the MgrA, hence expression of SarT/SarU induces expression of Skip. In this study, we uncovered one of the reason why the strains causing SSSS shows high expression of Skip.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Application of moisturizer to neonates prevents development of atopic dermatitis.2014
Author(s)
Horimukai K, Morita K, Narita M, Kondo M, Kitazawa H, Nozaki M, Shigematsu Y, Yoshida K, Niizeki H, Motomura K, Sago H, Takimoto T, Inoue E, Kamemura N, Kido H, Hisatsune J, Sugai M, Murota H, Katayama I, Sasaki T, Amagai M, Morita H, Matsuda A, Matsumoto K, Saito H, Ohya Y.
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Journal Title
The Journal of allergy and clinical immunology.
Volume: 134
Issue: 4
Pages: 824-830
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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