| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Cytolethal distending toxin (CDT-I) produced by Escherichia coli is encoded on lambdoid phage, and its phage induction is associated with the toxin production. We found that the induction level of CDT-I phage is different among the strains, and correlated with O serogroup of host E. coli including O127 and O142. The present study tried to identify the host factor which regulate CDT-I phage induction. Finally although we could not identify it during this research period, new findings could be obtained: (1) CDT-I phage induction is occurred in a RecA dependent pathway, and (2) intra-prophage interaction could be involved in the different CDT-I phage induction between CDT-I-producing E. coli O serogroups O127 and O142.
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