| Project/Area Number |
25860332
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Japan BCG Laboratory |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 結核 / 組換えタンパク / 脂質 / ワクチン |
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| Outline of Final Research Achievements |
In this study, we aimed to elicit an immune activating ability of Ag85B and mycolic acid (MA). In the natural state, Ag85B and MA were in the relationship between the enzyme and the substrate. Therefore we tried to mimic this Ag85B-MA fusion molecule which was thought to the best characteristics of both molecules, and tried to use for the development of new tuberculosis vaccine candidate. As a result, antigen and adjuvant combinations of enzymes (Ag85B) and substrate (MA), as compared to other common antigens (OVA) and MA, were resulting in higher antibody-inducing ability.
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