Study of signal mechanism of viral sensor protein RIG-I

• Project/Area Number: 25860337
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Virology
• Research Institution: Gakushuin University (2014); Kyoto University (2013)
• Principal Investigator: KIYOHIRO Takahasi 学習院大学, 理学部, 助教 (90399965)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 自然免疫 / インターフェロン / RIG-I / IPS-1 / シグナル伝達

Outline of Final Research Achievements

IPS-1 is found as an adaptor molecule that is necessary for induction of innate immunity. We found "domain 2" is the essential region that controls the activation of IPS-1 and suggest the model of IPS-1 activation. Now we are preparing the paper to be published.