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Analysis of hemorrhagic fever virus assembly and budding by visible technology

Research Project

Project/Area Number 25860342
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionNagasaki University

Principal Investigator

URATA Shuzo  長崎大学, 熱帯医学研究所, 助教 (20614449)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsウイルス
Outline of Final Research Achievements

1. Lassa virus Z has a mojor role on virus assembly and budding. We have shown that Z localized at late endosome(CD63 as a marker), and viral glycoprotein (GPC) facilitated this localization significantly. 2. Cellular factor, ALIX/AIP1, plays an important role on Z-mdeiated virus budding. 3. Z was tagged with Nano luc (Nluc) gene to establish high-through put screening system, and A549 stably expressing Z-Nluc cell line was cloned.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2015 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Cis- and cell type-dependent trans-requirements for Lassa virus-like particle production2015

    • Author(s)
      Shuzo Urata and Jiro Yasuda
    • Journal Title

      Journal of General Virology

      Volume: 印刷中

    • NAID

      120006986876

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] アレナウイルスの粒子形成・出芽解析2013

    • Author(s)
      浦田 秀造、安田 二朗
    • Organizer
      日本ウイルス学会学術集会
    • Place of Presentation
      神戸・神戸国際会議場
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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