| Project/Area Number |
25860348
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | HIV / SIV / 中和抗体 / CTL / エイズ / B細胞 |
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| Outline of Final Research Achievements |
We identified a subgroup of macaques inducing neutralizing antibodies (NAbs) against a highly antibody-resistant immunodeficiency virus strain SIVmac239, and compared virological and immunological profiles with NAb non-inducers. NAb inducers commonly showed prior selection a Nef mutant virus via specific patterns of CTL pressure. This mutant virus exerted a counterintuitive, proapoptotic property against Th cells showing dysfunctional accumulation in vivo, and also ameliorated suppression of B-cell maturation by wild-type Nef. These together comprise a hallmark boosting event for successful Ab responses in vivo.
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