| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
High-risk Human papillomaviruses (HR-HPVs), an etiological agent of cervical cancer, undergo three phases of the viral genome replication in the viral life cycle which is tightly linked to the differentiation status of stratified squamous epithelium. The aim of this study was to elucidate molecular mechanisms for switching the viral replication in keratinocytes, host for persistent infection of HPVs. We found that E1, a viral DNA helicase, activates NF-κB through ATR pathway and this activation of NF-κB limits E1 dependent-viral replication. Thus, E1 and NF-κB form a negative feedback loop which may function as a molecular switch for the viral genome replication.
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