Role of memory T helper cells and their maintenance in vivo
Project/Area Number |
25860352
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Chiba University |
Principal Investigator |
SHINODA Kenta 千葉大学, 医学(系)研究科(研究院), 助教 (10612195)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | アレルギー・喘息 / 免疫学 / アレルギー・ぜんそく |
Outline of Final Research Achievements |
To investigate the roles of bone marrow (BM) memory T helper (Th) cells, we evaluated humoral immune response of CD69-deficient mice which lacks them. We have clarified that BM memory Th cells are essential for efficient establishment for humoral immunity. On the other hands, it is known that there are memory Th cells that maintained at peripheral non-lymphoid tissues which are the sites of pathogen invasion. We focused on the maintenance of memory Th cells in lung tissue and found that memory Th cells are maintained within inducible bronchus-associated lymphoid tissue (iBALT). These studies will contribute the understanding of the role of memory Th cells and their maintenance in the body.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.2014
Author(s)
Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, DJ., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K. and Nakayama, T.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 111(35)
Issue: 35
Pages: 12829-34
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway.2014
Author(s)
Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, K. H., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.
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Journal Title
Immunity
Volume: 42
Pages: 294-308
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The polycomb protein Ezh2 regulates differentiation and plasticity of CD4+ T helper type-1 and type-2 cells.2013
Author(s)
Tumes, D. J., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., Motohashi, S., and Nakayama, T.
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Journal Title
Immunity
Volume: 39
Issue: 5
Pages: 819-32
DOI
Related Report
Peer Reviewed
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[Journal Article] Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.2013
Author(s)
Hosokawa H, Tanaka T, Kato M, Tohyama H, Hanazawa A, Tamaki Y, Hirahara K, Sakikawa I, Morita A, Nagira M, Suzuki Y, Nakayama T.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 110(46)
Issue: 46
Pages: 18626-18631
DOI
Related Report
Peer Reviewed
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[Journal Article] CD49b-dependent estabhshment of T helper cell memory.2013
Author(s)
Hanazawa, A., Hayashizaki, K.,Shinoda, K., Yagita, H., Okumura, K., Löhning, M., Hara, T., Tani-ichi, S., Ikuta, K., Eckes, B.,Radbruch, A., Tokoyoda, K, and Nakayama, T.
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Journal Title
Immuno1. Cell Bio1
Volume: 91
Issue: 8
Pages: 524-531
DOI
Related Report
Peer Reviewed
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[Presentation] Bach2-Blimp1 axis plays an important role in the regulation of allergic airway inflammation.2014
Author(s)
Izumoto, M., Kuwahara, M., Kiyoi, T., Shinoda, K., Nakayama, T., Kurosaki, T., and Yamashita, M.
Organizer
第43回日本免疫学会総会・学術集会
Place of Presentation
国立京都国際会館(京都府京都市)
Year and Date
2014-12-10 – 2014-12-12
Related Report
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[Presentation] The trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.2014
Author(s)
Watanabe, Y., Onodera, A., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Morimoto, Y., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K., and Nakayama, T.
Organizer
第43回日本免疫学会総会・学術集会
Place of Presentation
国立京都国際会館(京都府京都市)
Year and Date
2014-12-10 – 2014-12-12
Related Report
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[Presentation] Induction of anti-tumor effect of BCG-LM through activation of eosinophils and effector memory Th2 cells.
Author(s)
Ito, T., Hirahara, K., Suzuki, A., Shinoda, K., Hayashizaki, K., Wada, T., Yano, I., and Nakayama, T.
Organizer
第42回日本免疫学会総会学術集会
Place of Presentation
幕張メッセ(千葉県千葉市)
Related Report
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[Presentation] The histone methyltransferase Ezh2 regulates differentiation and plasticity of CD4 T helper cells.
Author(s)
Tumes, D., Onodera, A., Suzuki, A., Shinoda, K., Endo, Y., Iwamura, C., Hosokawa, H., Koseki, H., Tokoyoda, K., Suzuki, Y., and Nakayama, T.
Organizer
AAI Annual Meeting
Place of Presentation
Hawaii Convention Center (Honolulu, Hawaii, USA)
Related Report
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