| Project/Area Number |
25860356
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
WING James 大阪大学, 免疫学フロンティア研究センター, 特任助教 (00648694)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAGUCHI Shimon 大阪大学, 免疫学フロンティア研究センター, 教授 (30280770)
KUROSAKI Tomohiro 大阪大学, 免疫学フロンティア研究センター, 特任教授 (50178125)
ISE Wataru 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (70323483)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Regulatory T-cells / T follicular helper / Vaccination / Antibody response / T Follicular helper / Antibody responses / 制御性T細胞 / 免疫制御 |
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| Outline of Final Research Achievements |
I discovered that Tregs control the formation of Tfh and resulting B-cell germinal center reactions via the suppressive molecule CTLA-4. This is achieved by depletion of the costimulatory molecules CD80 and CD86 from the surface of antigen presenting B-cells and dendritic cells which are critical for the formation of Tfh. Since Tfh are vital for the production of high quality antibody responses and B-cell memory this means that Treg are able to control the production of antibody via CTLA-4.
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