• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Regulation of semaphorin molecules in development of colitis

Research Project

Project/Area Number 25860357
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

Kang Sujin  大阪大学, 医学(系)研究科(研究院), 寄附講座助教 (30644398)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordssemaphorin / colitis / セマフォリン / 感染 / 炎症性腸疾患
Outline of Final Research Achievements

Type I Innate lymphoid cells (ILCs) play an important roles in maintenance of intestinal homeostasis. In this study, we identified Sema4A, which is highly expressed in innate lymphoid cells is required for type I ILC activation. Using dextran-sodium induced mouse model, we found that Sema4A deficient mice showed enhanced body weight loss and shortening of colon length from day 5 on. In addition, Sema4A was preferentially expressed in CD8+ T cells in large intestine. Deletion of Sema4A restrained expression of effector molecules such as granzyme B, perfolin and FAS, resulting in susceptible for Listeria sp. infection. Our data demonstrated that Sema4A is essential to prevent excessive intestinal inflammation and for host defense for bacterial infection.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report

Research Products

(5 results)

All 2015

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (1 results) Book (1 results) Funded Workshop (1 results)

  • [Journal Article] mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.2015

    • Author(s)
      Ito D, Nojima S*, Nishide M, Okuno T, Takamatsu H, Kang S, Kimura T, Yoshida Y, Morimoto K, Maeda Y, Hosokawa T, Toyofuku T, Ohshima J, Kamimura D, Yamamoto M, Murakami M, Morii E, Rakugi H, Isaka Y, Kumanogoh A*. (* correspondence)
    • Journal Title

      J Immunol

      Volume: 195 Pages: 934-43

    • DOI

      10.4049/jimmunol.1403038

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Therapeutic uses of anti-interleukin-6 receptor antibody.2015

    • Author(s)
      Kang S, Tanaka T, Kishimoto T.
    • Journal Title

      International immmunology

      Volume: 27 Pages: 21-29

    • DOI

      10.1093/intimm/dxu081

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Semaphorin 6D controls macrophage polarization to prevent inflammatory diseases2015

    • Author(s)
      Sujin Kang, Yoshiyuki Kioi, Atsushi Kumanogoh
    • Organizer
      日本免疫学会
    • Place of Presentation
      北海道、札幌
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Book] Innovative Medicine: Basic Research and Development.2015

    • Author(s)
      T. Kishimoto, S. Kang, T. Tanaka
    • Total Pages
      339
    • Publisher
      Springer.
    • Related Report
      2015 Annual Research Report
  • [Funded Workshop] FOCIS2015

    • Place of Presentation
      San dieo, USA
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi