Role of IL-10 in the discrimination of pathogen and non-pathogen

• Project/Area Number: 25860359
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Kobe University
• Principal Investigator: HSOHI NAMIKO 神戸大学, 医学(系)研究科(研究院), 助教 (40645214)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: IL-10 / 病原菌 / 非病原菌 / 自然免疫 / インターロイキン 10 / インターロイキン 10

Outline of Final Research Achievements

We are exposed to many types of microorganisms in the surrounding environment, however, not all microorganisms can cause infectious disease. There should be a mechanism by which the host discriminate a bacteria between pathogen and non-pathogen, however, it is not fully understood. In this study we investigated whether regulatory cytokine IL-10 plays a role in the pathogen non-pathogen discrimination. Our data suggested that non-pathogenic bacteria Nissle 1917 has an ability to induce IL-10 superior to pathogenic C.roudentium. Only live but not heat-killed Nissle 1917 showed that ability.