| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Innate immune system is critical for the host defense against pathogens. However, a failure of its regulatory mechanism triggers the pathogenesis of diseases such as autoimmune disorders. In this study, we investigated the activation and suppression mechanisms of IRF5, a transcription factor important for the innate immune responses. As a result, we found that IRF5 is activated through ubiquitination followed by phosphorylation, and that an IRF5-binding protein Lyn suppresses these post-translational modifications, thereby preventing the hyperactivation of IRF5. Our findings might facilitate the development of new therapeutics for the diseases that target IRF5, such as systemic lupus erythematosus.
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