Understanding the novel regulatory mechanism of transcription factors in innate immune responses
Project/Area Number |
25860368
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Immunology
|
Research Institution | Yokohama City University |
Principal Investigator |
BAN Tatsuma 横浜市立大学, 医学部, 助教 (50635357)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 自然免疫応答 / 転写因子 / 自己免疫疾患 / 全身性エリテマトーデス / 翻訳後修飾 / IRF5 |
Outline of Final Research Achievements |
Innate immune system is critical for the host defense against pathogens. However, a failure of its regulatory mechanism triggers the pathogenesis of diseases such as autoimmune disorders. In this study, we investigated the activation and suppression mechanisms of IRF5, a transcription factor important for the innate immune responses. As a result, we found that IRF5 is activated through ubiquitination followed by phosphorylation, and that an IRF5-binding protein Lyn suppresses these post-translational modifications, thereby preventing the hyperactivation of IRF5. Our findings might facilitate the development of new therapeutics for the diseases that target IRF5, such as systemic lupus erythematosus.
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Report
(4 results)
Research Products
(3 results)