The effects of TSLP-responsive dendritic cells on the allergic reaction in the skin
| Project/Area Number |
25860369
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アレルギー / 樹状細胞 / 表皮ケラチノサイト / TSLP |
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| Outline of Final Research Achievements |
In this study, I have been identifying subsets of dendritic cells that were capable of migrating into skin-draining lymph nodes from the skin where a cytokine thymic stromal lymphopoietin, TSLP, was expressed. The results indicated that at least five subsets of TSLP-responsive dendritic cells could potentially exist. The co-culture between TSLP-responsive subsets of dendritic cells and TSLP-receptor deficient naive helper T cells resulted in the finding that one subset of dendritic cells could prime helper T cells into Th2 cytokine-producing Th2 cells. The cytokines produced by these helper T cells could induce the expressions and/or activation of transcription factors in epidermal keratinocytes, the events that may be associated with disruption of homeostasis of epidermis of atopic dermatitis.
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Report
(4 results)
Research Products
(4 results)
