| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, I have been identifying subsets of dendritic cells that were capable of migrating into skin-draining lymph nodes from the skin where a cytokine thymic stromal lymphopoietin, TSLP, was expressed. The results indicated that at least five subsets of TSLP-responsive dendritic cells could potentially exist. The co-culture between TSLP-responsive subsets of dendritic cells and TSLP-receptor deficient naive helper T cells resulted in the finding that one subset of dendritic cells could prime helper T cells into Th2 cytokine-producing Th2 cells. The cytokines produced by these helper T cells could induce the expressions and/or activation of transcription factors in epidermal keratinocytes, the events that may be associated with disruption of homeostasis of epidermis of atopic dermatitis.
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