The examination of mechanism of specific rejection

• Project/Area Number: 25860370
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Osaka Medical College
• Principal Investigator: Inoue Yoshihiro 大阪医科大学, 医学部, 助教 (90646762)
• Research Collaborator: Uchiyama Kazuhisa (80232867) ; Yoshida Ryotaro
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 移植免疫 / 主要組織適合性抗原 / 移植拒絶反応 / 発現量 / 抗原の数 / 移植片拒絶 / 移植皮膚 / トランスジェニックマウス / MMR1 / MMR2

Outline of Final Research Achievements

Dd and Kd genes are equivalent as allogeneic MHC class I genes and that
C57BL/6 (DbKb) mice reject Dd-, Kd-, or DdKd-transgened skin or tumor cells in a transgene numberdependent, gene expression rate-independent manner.
Using our new MHC class I transgenic strains of mice, we could not define whether allografts are controlled by alloreactive cytotoxic macrophages via MMR1 and MMR2 receptors or by R15 and R12.