| Project/Area Number |
25860374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SEO WOOSEOK 独立行政法人理化学研究所, 統合生命医科学研究センター, 国際特別研究員 (40574116)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | CD4T細胞 / Runx1転写因子 / long non-coding RNA / ヒト喘息疾患発症 / CD4+ T 細胞 |
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| Outline of Final Research Achievements |
Runx1 knockout mice spontaneously develop lung inflammation resembling human asthma; however, its mechanism is not known yet. Examination of Runx1 locus shows a long non-coding RNA (lncRNA) located near Runx1 gene. This novel lncRNA shows a very low expression, but it is restricted to helper T lymphocytes. Knockdown of Runx1-lncRNA shows differential expressions of Runx1 target genes. Also, Runx1-lncRNA knockout mouse develops lung pathologies similar to Runx1 knockout mice. Therefore, we conclude that Runx1-lncRNA is functionally related to Runx1 protein.
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